Detalhe da pesquisa
1.
Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors.
Chemistry
; 22(4): 1313-21, 2016 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26560738
2.
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.
Int J Cancer
; 136(9): 2078-90, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25302649
3.
New Trends in Aging Drug Discovery.
Biomedicines
; 10(8)2022 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36009552
4.
2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease.
J Med Chem
; 65(18): 12256-12272, 2022 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36044544
5.
Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity".
J Med Chem
; 65(7): 5449-5461, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35349261
6.
A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.
Breast Cancer Res
; 13(6): R131, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22177475
7.
Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.
Oncotarget
; 8(7): 11600-11613, 2017 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28086243
8.
A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.
Sci Rep
; 7: 41293, 2017 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28117458
9.
A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity.
J Med Chem
; 60(23): 9575-9584, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29116785
10.
A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.
J Med Chem
; 48(13): 4216-9, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15974573
11.
Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.
J Med Chem
; 48(7): 2548-58, 2005 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15801844
12.
Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.
Eur J Pharmacol
; 511(1): 9-19, 2005 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15777774
13.
Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists.
J Med Chem
; 45(22): 4806-15, 2002 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12383006
14.
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.
J Med Chem
; 46(26): 5638-50, 2003 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-14667218
15.
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.
J Med Chem
; 57(17): 7160-81, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24850589
16.
The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.
J Med Chem
; 57(15): 6879-84, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25073094
17.
New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.
J Med Chem
; 56(20): 7851-61, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24050112
18.
New synthetic inhibitors of fatty acid synthase with anticancer activity.
J Med Chem
; 55(11): 5013-23, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22559865
19.
Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy.
J Med Chem
; 54(4): 1096-100, 2011 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21271718
20.
New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.
J Med Chem
; 54(23): 7986-99, 2011 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22029386