Detalhe da pesquisa
1.
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Brain
; 147(5): 1784-1798, 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38387080
2.
Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis.
Proc Natl Acad Sci U S A
; 119(13): e2023784119, 2022 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35333654
3.
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc Natl Acad Sci U S A
; 111(35): 12853-8, 2014 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25136132
4.
A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development.
Brain
; 138(Pt 8): 2147-60, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26068709
5.
Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.
Mol Ther
; 22(8): 1530-1543, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24832007
6.
Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases.
J Huntingtons Dis
; 10(1): 203-220, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-32925081
7.
Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease.
Front Aging Neurosci
; 12: 242, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33117143
8.
Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model.
Brain Commun
; 2(2): fcaa066, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32954323
9.
Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.
J Neurosci
; 28(42): 10720-33, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18923047
10.
The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease.
J Cell Mol Med
; 13(8B): 2645-2657, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19602042
11.
Physiology of Hyperuricemia and Urate-Lowering Treatments.
Front Med (Lausanne)
; 5: 160, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29904633
12.
Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice.
J Neurosci
; 26(52): 13548-55, 2006 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17192438
13.
Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.
Sci Rep
; 7(1): 11900, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28928414
14.
Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter.
Front Mol Neurosci
; 10: 40, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28289374
15.
Targeting the cAMP and Transforming Growth Factor-ß Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium.
Stem Cells Transl Med
; 5(7): 925-37, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27112176
16.
Neurotransmitter receptor analysis in transgenic mouse models.
Methods Mol Biol
; 277: 231-60, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15201460
17.
SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease.
PLoS One
; 6(11): e27746, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22140466
18.
Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease.
J Neuropathol Exp Neurol
; 69(8): 817-27, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20613636
19.
Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease.
PLoS One
; 4(6): e5747, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19484127
20.
Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease.
Mol Neurodegener
; 3: 17, 2008 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18954449