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1.
Inf Serv Use ; 42(1): 107-115, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35600117

RESUMO

The highest priority new initiative resulting from the 1985-86 National Library of Medicine Long Range Planning exercise initiated by NLM Director Dr. Donald A.B. Lindberg was the creation of new information resources and services related to molecular biology and genetics, termed "biotechnology information". Beginning with existing NLM resources and research projects associated with molecular data, and with Lindberg's enthusiastic support, the institution launched a Congressionally-mandated Center that has become an essential part of 21st century biomedical science.

2.
Nucleic Acids Res ; 46(D1): D41-D47, 2018 01 04.
Artigo em Inglês | MEDLINE | ID: mdl-29140468

RESUMO

GenBank® (www.ncbi.nlm.nih.gov/genbank/) is a comprehensive database that contains publicly available nucleotide sequences for 400 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole genome shotgun and environmental sampling projects. Most submissions are made using BankIt, the National Center for Biotechnology Information (NCBI) Submission Portal, or the tool tbl2asn. GenBank staff assign accession numbers upon data receipt. Daily data exchange with the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through the NCBI Nucleotide database, which links to related information such as taxonomy, genomes, protein sequences and structures, and biomedical journal literature in PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. Recent updates include changes to sequence identifiers, submission wizards for 16S and Influenza sequences, and an Identical Protein Groups resource.


Assuntos
Bases de Dados de Ácidos Nucleicos , Animais , Biologia Computacional , Bases de Dados de Ácidos Nucleicos/estatística & dados numéricos , Bases de Dados de Ácidos Nucleicos/tendências , Europa (Continente) , Genômica , Humanos , Disseminação de Informação , Armazenamento e Recuperação da Informação , Internet , Japão , National Library of Medicine (U.S.) , Orthomyxoviridae/genética , Proteômica , RNA Ribossômico/genética , Alinhamento de Sequência , Estados Unidos
3.
Nucleic Acids Res ; 45(D1): D37-D42, 2017 01 04.
Artigo em Inglês | MEDLINE | ID: mdl-27899564

RESUMO

GenBank® (www.ncbi.nlm.nih.gov/genbank/) is a comprehensive database that contains publicly available nucleotide sequences for 370 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or the NCBI Submission Portal. GenBank staff assign accession numbers upon data receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Nucleotide database, which links to related information such as taxonomy, genomes, protein sequences and structures, and biomedical journal literature in PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. Recent updates include changes to policies regarding sequence identifiers, an improved 16S submission wizard, targeted loci studies, the ability to submit methylation and BioNano mapping files, and a database of anti-microbial resistance genes.


Assuntos
Bases de Dados de Ácidos Nucleicos , Análise de Sequência de DNA , Animais , Metilação de DNA , Genoma Bacteriano , Genômica , Humanos , RNA Ribossômico 16S/genética , beta-Lactamases/genética
4.
Nucleic Acids Res ; 43(Database issue): D30-5, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25414350

RESUMO

GenBank(®) (http://www.ncbi.nlm.nih.gov/genbank/) is a comprehensive database that contains publicly available nucleotide sequences for over 300 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assign accession numbers upon data receipt. Daily data exchange with the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP.


Assuntos
Bases de Dados de Ácidos Nucleicos , Bactérias/classificação , Genômica , Internet , Análise de Sequência de DNA , Análise de Sequência de Proteína
5.
Nucleic Acids Res ; 42(Database issue): D32-7, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24217914

RESUMO

GenBank is a comprehensive database that contains publicly available nucleotide sequences for over 280,000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assign accession numbers upon data receipt. Daily data exchange with the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through the National Center for Biotechnology Information (NCBI) Entrez retrieval system, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI home page: www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados de Ácidos Nucleicos , Análise de Sequência de DNA , Bactérias/classificação , Bactérias/genética , Sequenciamento de Nucleotídeos em Larga Escala , Internet , Anotação de Sequência Molecular
6.
Nucleic Acids Res ; 41(Database issue): D36-42, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23193287

RESUMO

GenBank® (http://www.ncbi.nlm.nih.gov) is a comprehensive database that contains publicly available nucleotide sequences for almost 260 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assigns accession numbers upon data receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI home page: www.ncbi.nlm.nih.gov.


Assuntos
Sequência de Bases , Bases de Dados de Ácidos Nucleicos , Genômica , Sequenciamento de Nucleotídeos em Larga Escala , Internet , Anotação de Sequência Molecular , Análise de Sequência de DNA
7.
Nucleic Acids Res ; 40(Database issue): D48-53, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22144687

RESUMO

GenBank® is a comprehensive database that contains publicly available nucleotide sequences for more than 250,00 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI home page: www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados de Ácidos Nucleicos , Análise de Sequência de DNA , Genômica , Sequenciamento de Nucleotídeos em Larga Escala , Internet , Anotação de Sequência Molecular , Análise de Sequência de RNA , Interface Usuário-Computador
8.
Nucleic Acids Res ; 40(Database issue): D13-25, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22140104

RESUMO

In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Website. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, Genome and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, BioProject, BioSample, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Probe, Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), Biosystems, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados como Assunto , Bases de Dados Genéticas , Bases de Dados de Proteínas , Expressão Gênica , Genômica , Internet , Modelos Moleculares , National Library of Medicine (U.S.) , Publicações Periódicas como Assunto , PubMed , Alinhamento de Sequência , Análise de Sequência de DNA , Análise de Sequência de Proteína , Análise de Sequência de RNA , Bibliotecas de Moléculas Pequenas , Estados Unidos
9.
Nucleic Acids Res ; 39(Database issue): D32-7, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21071399

RESUMO

GenBank® is a comprehensive database that contains publicly available nucleotide sequences for more than 380,000 organisms named at the genus level or lower, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system that integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI Homepage: www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados de Ácidos Nucleicos , Etiquetas de Sequências Expressas , Genômica , Sequenciamento de Nucleotídeos em Larga Escala , Metagenômica , Anotação de Sequência Molecular , Software
10.
Nucleic Acids Res ; 39(Database issue): D38-51, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21097890

RESUMO

In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Electronic PCR, OrfFinder, Splign, ProSplign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), IBIS, Biosystems, Peptidome, OMSSA, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados Genéticas , Bases de Dados de Proteínas , Expressão Gênica , Genômica , National Library of Medicine (U.S.) , Estrutura Terciária de Proteína , PubMed , Alinhamento de Sequência , Análise de Sequência de DNA , Análise de Sequência de RNA , Software , Integração de Sistemas , Estados Unidos
11.
Nucleic Acids Res ; 38(Database issue): D46-51, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19910366

RESUMO

GenBank is a comprehensive database that contains publicly available nucleotide sequences for more than 300,000 organisms named at the genus level or lower, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the European Molecular Biology Laboratory Nucleotide Sequence Database in Europe and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bi-monthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI homepage: www.ncbi.nlm.nih.gov.


Assuntos
Biologia Computacional/métodos , Bases de Dados Genéticas , Bases de Dados de Ácidos Nucleicos , Algoritmos , Animais , Biologia Computacional/tendências , Bases de Dados de Proteínas , Etiquetas de Sequências Expressas , Genoma Bacteriano , Genoma de Planta , Genoma Viral , Humanos , Armazenamento e Recuperação da Informação/métodos , Internet , National Institutes of Health (U.S.) , National Library of Medicine (U.S.) , Software , Estados Unidos
12.
Nucleic Acids Res ; 38(Database issue): D5-16, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19910364

RESUMO

In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, Reference Sequence, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Peptidome, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.


Assuntos
Biologia Computacional/métodos , Bases de Dados Genéticas , Bases de Dados de Ácidos Nucleicos , Algoritmos , Animais , Biologia Computacional/tendências , Bases de Dados de Proteínas , Genoma Bacteriano , Genoma Viral , Humanos , Armazenamento e Recuperação da Informação/métodos , Internet , National Institutes of Health (U.S.) , National Library of Medicine (U.S.) , Software , Estados Unidos
13.
Stud Health Technol Inform ; 288: 113-121, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-35102833

RESUMO

The highest priority new initiative resulting from the 1985-86 National Library of Medicine Long Range Planning exercise initiated by NLM Director Dr. Donald A.B. Lindberg was the creation of new information resources and services related to molecular biology and genetics, termed "biotechnology information". Beginning with existing NLM resources and research projects associated with molecular data, and with Lindberg's enthusiastic support, the institution launched a Congressionally-mandated Center that has become an essential part of 21st century biomedical science.


Assuntos
Biotecnologia , Biologia Computacional , National Library of Medicine (U.S.) , Coleta de Dados , Projeto Genoma Humano , Estados Unidos
14.
Nucleic Acids Res ; 37(Database issue): D26-31, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18940867

RESUMO

GenBank is a comprehensive database that contains publicly available nucleotide sequences for more than 300,000 organisms named at the genus level or lower, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank(R) staff upon receipt. Daily data exchange with the European Molecular Biology Laboratory Nucleotide Sequence Database in Europe and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through the National Center for Biotechnology Information (NCBI) Entrez retrieval system, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI Homepage: www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados de Ácidos Nucleicos , Animais , Etiquetas de Sequências Expressas/química , Genômica , Humanos , Internet , Sitios de Sequências Rotuladas
15.
Nucleic Acids Res ; 37(Database issue): D5-15, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18940862

RESUMO

In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubChem suite of small molecule databases. Augmenting many of the web applications is custom implementation of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados Genéticas , Expressão Gênica , Genes , Genômica , Genótipo , National Library of Medicine (U.S.) , Fenótipo , Estrutura Terciária de Proteína , Proteômica , PubMed , Homologia de Sequência , Integração de Sistemas , Estados Unidos
16.
Nucleic Acids Res ; 36(Database issue): D25-30, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18073190

RESUMO

GenBank (R) is a comprehensive database that contains publicly available nucleotide sequences for more than 260 000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the European Molecular Biology Laboratory Nucleotide Sequence Database in Europe and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through NCBI's retrieval system, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI Homepage: www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados de Ácidos Nucleicos , Análise de Sequência de DNA , DNA Complementar/química , Etiquetas de Sequências Expressas/química , Genômica , Internet , National Library of Medicine (U.S.) , Estados Unidos , Interface Usuário-Computador
17.
Nucleic Acids Res ; 36(Database issue): D13-21, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18045790

RESUMO

In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data available through NCBI's web site. NCBI resources include Entrez, the Entrez Programming Utilities, My NCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link, Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genome, Genome Project and related tools, the Trace, Assembly, and Short Read Archives, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups, Influenza Viral Resources, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Database of Genotype and Phenotype, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite of small molecule databases. Augmenting the web applications are custom implementations of the BLAST program optimized to search specialized data sets. These resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados Genéticas , National Library of Medicine (U.S.) , Animais , Bases de Dados de Ácidos Nucleicos , Expressão Gênica , Genômica , Genótipo , Humanos , Internet , Modelos Moleculares , Fenótipo , Proteômica , Alinhamento de Sequência , Estados Unidos
18.
Nucleic Acids Res ; 35(Database issue): D21-5, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17202161

RESUMO

GenBank (R) is a comprehensive database that contains publicly available nucleotide sequences for more than 240 000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in Europe and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through NCBI's retrieval system, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI Homepage (www.ncbi.nlm.nih.gov).


Assuntos
Bases de Dados de Ácidos Nucleicos , Animais , Sequência de Bases , DNA Complementar/química , Etiquetas de Sequências Expressas/química , Genômica , Humanos , Internet , National Library of Medicine (U.S.) , Sitios de Sequências Rotuladas , Estados Unidos , Interface Usuário-Computador
19.
Nucleic Acids Res ; 35(Database issue): D5-12, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17170002

RESUMO

In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, the Entrez Programming Utilities, My NCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link(BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genome, Genome Project and related tools, the Trace and Assembly Archives, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Viral Genotyping Tools, Influenza Viral Resources, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. These resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados Genéticas , National Library of Medicine (U.S.) , Animais , Bases de Dados de Ácidos Nucleicos , Bases de Dados de Proteínas , Expressão Gênica , Genômica , Humanos , Internet , Fenótipo , Proteômica , PubMed , Alinhamento de Sequência , Software , Estados Unidos
20.
Nucleic Acids Res ; 34(Database issue): D16-20, 2006 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-16381837

RESUMO

GenBank (R) is a comprehensive database that contains publicly available DNA sequences for more than 205 000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the Web-based BankIt or standalone Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in Europe and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through NCBI's retrieval system, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, go to the NCBI Homepage at www.ncbi.nlm.nih.gov.


Assuntos
Bases de Dados de Ácidos Nucleicos , Animais , Sequência de Bases , Bovinos , DNA/química , DNA Complementar/química , Etiquetas de Sequências Expressas/química , Genômica , Humanos , Internet , Camundongos , Ratos , Sitios de Sequências Rotuladas , Interface Usuário-Computador
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