Detalhe da pesquisa
1.
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells.
Mol Pharm
; 16(8): 3361-3373, 2019 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31265310
2.
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.
BMC Cancer
; 17(1): 51, 2017 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28086830
3.
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1.
Pharmacol Res
; 117: 67-74, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28007569
4.
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands.
Arch Pharm (Weinheim)
; 349(3): 161-7, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26750618
5.
Novel and Selective Fluorescent σ2 -Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells.
Chembiochem
; 16(7): 1078-83, 2015 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25757101
6.
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview.
Rev Neurosci
; 25(3): 401-15, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24622785
7.
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor.
Bioorg Med Chem
; 22(5): 1736-50, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24508140
8.
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors.
Chem Biodivers
; 11(2): 299-310, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24591318
9.
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.
Bioorg Med Chem Lett
; 23(5): 1370-4, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374872
10.
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments.
Bioorg Med Chem Lett
; 23(13): 3728-31, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23726026
11.
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.
Bioorg Med Chem Lett
; 23(22): 6083-6, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24100077
12.
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters.
Exp Brain Res
; 230(4): 569-82, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23571499
13.
Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines.
Bioorg Med Chem
; 21(7): 1865-9, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23415062
14.
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.
Bioorg Med Chem
; 21(5): 1324-32, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23347803
15.
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect.
Eur J Med Chem
; 228: 114038, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34902734
16.
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands.
Bioorg Med Chem
; 19(24): 7612-22, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22075234
17.
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models.
Cell Oncol (Dordr)
; 44(6): 1307-1323, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34586588
18.
Identification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT(1A) receptors.
Bioorg Med Chem Lett
; 20(22): 6628-32, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20888762
19.
Radiosynthesis and in vivo evaluation of [(11)C]MC80 for P-glycoprotein imaging.
Bioorg Med Chem
; 18(17): 6489-95, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20685124
20.
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti-SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships.
Front Pharmacol
; 11: 589810, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33364961