Detalhe da pesquisa
1.
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc Natl Acad Sci U S A
; 121(15): e2317274121, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579010
2.
Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase.
J Biol Chem
; 288(25): 18260-70, 2013 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23661699
3.
Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 2): 134-43, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22281742
4.
Structural and functional studies of mycobacterial IspD enzymes.
Acta Crystallogr D Biol Crystallogr
; 67(Pt 5): 403-14, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21543842
5.
From screen to structure with a harvestable microfluidic device.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 8): 971-5, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21821908
6.
Screening cells for crystals: a synergistic approach.
J Appl Crystallogr
; 53(Pt 6): 1414-1415, 2020 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33304219
7.
Author Correction: Inhibition of translation termination by small molecules targeting ribosomal release factors.
Sci Rep
; 10(1): 4950, 2020 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32170142
8.
Inhibition of translation termination by small molecules targeting ribosomal release factors.
Sci Rep
; 9(1): 15424, 2019 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31659219
9.
Crystal structures of a family 19 chitinase from Brassica juncea show flexibility of binding cleft loops.
FEBS J
; 274(14): 3695-3703, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17608716
10.
Screening and optimization methods for nonautomated crystallization laboratories.
Methods Mol Biol
; 363: 131-51, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17272840
11.
Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function.
J Mol Biol
; 351(5): 1048-56, 2005 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16051262
12.
Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with ß-Arylpropyl Analogues of Fosmidomycin.
ChemMedChem
; 11(18): 2024-36, 2016 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27487410
13.
The crystal structure of Echinococcus granulosus fatty-acid-binding protein 1.
Biochim Biophys Acta
; 1649(1): 40-50, 2003 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-12818189
14.
Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.
J Mol Biol
; 335(3): 799-809, 2004 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-14687575
15.
Synthesis and bioactivity of ß-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
J Med Chem
; 58(7): 2988-3001, 2015 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25781377
16.
Microseed matrix screening for optimization in protein crystallization: what have we learned?
Acta Crystallogr F Struct Biol Commun
; 70(Pt 9): 1117-26, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25195878
17.
DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.
J Med Chem
; 56(15): 6190-9, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23819803
18.
Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.
Open Biol
; 2(1): 110026, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22645655
19.
Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
J Med Chem
; 54(14): 4964-76, 2011 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21678907
20.
X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation.
J Mol Biol
; 376(1): 109-19, 2008 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18155238