Detalhe da pesquisa
1.
Discovery of MDV6058 (PF-06952229), a selective and potent TGFßR1 inhibitor: Design, synthesis and optimization.
Bioorg Med Chem Lett
; 75: 128979, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36089110
2.
Dual Inhibition of Bruton's Tyrosine Kinase and Phosphoinositide-3-Kinase p110δ as a Therapeutic Approach to Treat Non-Hodgkin's B Cell Malignancies.
J Pharmacol Exp Ther
; 361(2): 312-321, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28298527
3.
Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR.
Bioorg Med Chem Lett
; 27(2): 217-222, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27923618
4.
Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors.
Bioorg Med Chem Lett
; 27(10): 2153-2160, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28377059
5.
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.
Bioorg Med Chem Lett
; 26(21): 5222-5228, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27717544
6.
Temozolomide analogs with improved brain/plasma ratios - Exploring the possibility of enhancing the therapeutic index of temozolomide.
Bioorg Med Chem Lett
; 26(20): 5103-5109, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27614414
7.
Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease.
J Immunol
; 190(10): 5048-56, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23589621
8.
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide.
Breast Cancer Res
; 16(1): R7, 2014 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24451109
9.
Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
J Immunol
; 188(7): 3062-70, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22379034
10.
Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer.
Prostate
; 73(12): 1291-305, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23765603
11.
Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation.
Aging Cell
; 22(5): e13814, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36973898
12.
Rapid isothermal point-of-care test for screening of SARS-CoV-2 (COVID-19).
Asp Mol Med
; 1: 100002, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37519861
13.
Suppression of Ah Receptor (AhR) increases the aggressiveness of TNBC cells and 11-Cl-BBQ-activated AhR inhibits their growth.
Biochem Pharmacol
; 215: 115706, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506922
14.
Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline.
ACS Pharmacol Transl Sci
; 6(7): 1028-1042, 2023 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37470014
15.
Eisosomes mark static sites of endocytosis.
Nature
; 439(7079): 998-1003, 2006 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16496001
16.
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease.
Sci Signal
; 14(668)2021 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33531382
17.
The unfolded protein response during prostate cancer development.
Cancer Metastasis Rev
; 28(1-2): 219-23, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19172382
18.
Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism.
J Pharmacol Exp Ther
; 333(3): 748-57, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20194526
19.
Small molecule cognitive enhancer reverses age-related memory decline in mice.
Elife
; 92020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33258451
20.
Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma.
J Neurotrauma
; 37(11): 1370-1380, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31884883