COVID and nutrition: A machine learning perspective.

A self-report questionnaire survey was conducted online to collect big data from over 16000 Iranian families (who were the residents of 1000 urban and rural areas of Iran). The resulting data storage contained over 1 M records of data and over 1G records of automatically inferred information. Based on this data storage, a series of machine learning experiments was conducted to investigate the relationship between nutrition and the risk of contracting COVID-19. With highly accurate scores, the findings strongly suggest that foods and water sources containing certain natural bioactive and phytochemical agents may help to reduce the risk of apparent COVID-19 infection.

Some natural hypomethylating agents in food, water and environment are against distribution and risks of COVID-19 pandemic: Results of a big-data research.

Objective: This study analyzes the effects of lifestyle, nutrition, and diets on the status and risks of apparent (symptomatic) COVID-19 infection in Iranian families. Materials and Methods: A relatively extensive questionnaire survey was conducted on more than 20,000 Iranian families (residing in more than 1000 different urban and rural areas in the Islamic Republic of Iran) to collect the big data of COVID-19 and develop a lifestyle dataset. The collected big data included the records of lifestyle effects (e.g. nutrition, water consumption resources, physical exercise, smoking, age, gender, health and disease factors, etc.) on the status of COVID-19 infection in families (i.e. residents of homes). Therefore, an online self-reported questionnaire was used in this retrospective observational study to analyze the effects of lifestyle factors on the COVID-19 risks. The data collection process spanned from May 10, 2020 to March 19, 2021 by selecting 132 samples from more than 40 different social network communities. Results: The research results revealed that food and water sources, which contain some natural hypomethylating agents, mitigated the risks of apparent (symptomatic) COVID-19 infection. Furthermore, the computations on billions of permutations of nutrition conditions and dietary regime items, based on the data collected from people's diets and infection status, showed that there were many dietary conditions alleviating the risks of apparent (symptomatic) COVID-19 infection by 90%. However, some other diets tripled the infection risk. Conclusion: Some natural hypomethylating agents in food, water, and environmental resources are against the spread and risks of COVID-19.

Subconjunctival bevacizumab injection in treatment of pterygium.

This study determined the clinical effect of subconjunctival administration of bevacizumab in patients with primary and recurrent pterygium. The study was an off-label, single-dosing, interventional case series involving 22 patients with primary and recurrent pterygium. They received subconjunctival bevacizumab (0.2 cc). Pterygium vascularity and thickness was graded. The size of the pterygium (measured by surface area in cm2) was recorded from baseline to 12 weeks, after injection. Treatment-related complications and adverse events were reported. The main outcome of measurements was the change in size, vascularity, thickness, color intensity. There were 15 males (68.2%) and 7 females (31.8%) of 22 patients with a mean age of 45.5 years (SD 11.68 years). One cases didn't cooperate, and excluded. There was a significant difference in the mean surface area of pterygium at different intervals (P < 0.05) and the size of pterygium was reduced. On comparison of the mean pterygium size, there was no significant difference between men and women (P >0.05). There was a significant reduction in the mean pterygium size of patients younger than 45 years in comparison to those older than 45 years after three month (P =0.037), but after 6 months, this difference was not significant (P = 0.338). Average changes in pterygium size for both eyes were not different. The reduction of color intensity in both eyes was significant (P =0.031). Subconjuctival bevacizumab injection is useful in management of patients with primary and recurrent pterygium without significant local or systemic adverse effects.

Corneal topographic changes in healthy siblings of patients with keratoconus.

AIM: To describe the involvement in relatives of keratoconus (KCN) patients with corneal topography map. METHODS: A total of 150 siblings of 300 eyes of 75 KCN patients referred to corneal clinic were studied and experienced complete slit-lamp, refraction examinations and topographic cornea maps provided by videophotoker-atography. ANOVA, Fisher exact and Chi-square tests performed to compare of results. RESULTS: Of 150 siblings, 56% were female and 44% were male with average age of 21 (range 15-39) years. KCN and suspect KCN diagnosed in 12.3% and 6.6% respectively. The central keratometry (CK) was 46.5±4.51 dioptr (D) in KCN and 45.66±1.52D in suspect KCN. Inferior-superior value (I-S) was 3.51±2.5D in KCN and 1.56±1.22D in suspect KCN. In KCN condition the oval pattern was 67.6% (n=25) and Round pattern detected 32.4% (n=12). In suspect KCN these patterns detected 90% and 10% respectively. Refractive errors in KCN were -7.5 to +1.25 dioptr (-1.25±1.83), in suspect KCN 0.45 to -4.2 dioptr (-0.68±0.76) and in healthy group 2.75 to -7.5 dioptr (-0.6±1.12). Astigmatism was mild in 22.7%, moderate and sever astigmatism in 18.3% in KCN and suspect KCN CONCLUSION: Increasing KCN condition in healthy siblings of KCN patients shows require to screening plan to early diagnose and cautionly treatment of contact lens in these individuals.