Detalhe da pesquisa
1.
Mechanistic insight into the enzymatic reduction of truncated hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A motif in electron cycling.
J Biol Chem
; 289(31): 21573-83, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24928505
2.
Novel 11ß-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold.
Bioorg Med Chem Lett
; 25(19): 4250-3, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26306982
3.
Searching for novel applications of the benzohomoadamantane scaffold in medicinal chemistry: Synthesis of novel 11ß-HSD1 inhibitors.
Bioorg Med Chem
; 23(24): 7607-17, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26596711
4.
An 'open' structure of the RecOR complex supports ssDNA binding within the core of the complex.
Nucleic Acids Res
; 41(16): 7972-86, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23814185
5.
Comparative analysis of inner cavities and ligand migration in non-symbiotic AHb1 and AHb2.
Biochim Biophys Acta
; 1834(9): 1957-67, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23583621
6.
Kinetics and computational studies of ligand migration in nitrophorin 7 and its Δ1-3 mutant.
Biochim Biophys Acta
; 1834(9): 1711-21, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23624263
7.
Ligand migration through hemeprotein cavities: insights from laser flash photolysis and molecular dynamics simulations.
Phys Chem Chem Phys
; 15(26): 10686-701, 2013 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23733145
8.
MDpocket: open-source cavity detection and characterization on molecular dynamics trajectories.
Bioinformatics
; 27(23): 3276-85, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21967761
9.
Oxygen binding to Arabidopsis thaliana AHb2 nonsymbiotic hemoglobin: evidence for a role in oxygen transport.
IUBMB Life
; 63(5): 355-62, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21618402
10.
Molecular modeling of class I and II alleles of the major histocompatibility complex in Salmo salar.
J Comput Aided Mol Des
; 24(12): 1035-51, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20936494
11.
Modulating Ligand Dissociation through Methyl Isomerism in Accessory Sites: Binding of Retinol to Cellular Carriers.
J Phys Chem Lett
; 10(23): 7333-7339, 2019 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31714784
12.
Deficiency of perforin and hCNT1, a novel inborn error of pyrimidine metabolism, associated with a rapidly developing lethal phenotype due to multi-organ failure.
Biochim Biophys Acta Mol Basis Dis
; 1865(6): 1182-1191, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30658162
13.
Mechanism of product release in NO detoxification from Mycobacterium tuberculosis truncated hemoglobin N.
J Am Chem Soc
; 130(5): 1688-93, 2008 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-18189394
14.
Nitric oxide reactivity with globins as investigated through computer simulation.
Methods Enzymol
; 437: 477-98, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18433643
15.
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
J Med Chem
; 51(12): 3588-98, 2008 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18517184
16.
Electrostatic Tuning of the Ligand Binding Mechanism by Glu27 in Nitrophorin 7.
Sci Rep
; 8(1): 10855, 2018 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30022039
17.
Design, synthesis and in vivo study of novel pyrrolidine-based 11ß-HSD1 inhibitors for age-related cognitive dysfunction.
Eur J Med Chem
; 139: 412-428, 2017 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28818766
18.
Ligand-induced dynamical regulation of NO conversion in Mycobacterium tuberculosis truncated hemoglobin-N.
Proteins
; 64(2): 457-64, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16688782
19.
The N-terminal pre-A region of Mycobacterium tuberculosis 2/2HbN promotes NO-dioxygenase activity.
FEBS J
; 283(2): 305-22, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26499089
20.
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
J Med Chem
; 48(23): 7223-33, 2005 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16279781