Detalhe da pesquisa
1.
Impact of Siponimod on Enteric and Central Nervous System Pathology in Late-Stage Experimental Autoimmune Encephalomyelitis.
Int J Mol Sci
; 23(22)2022 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430692
2.
Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity.
J Immunol
; 203(11): 2791-2806, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31659015
3.
Blockade of CD40-CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD/ShiLtJ mouse model of Sjögren's syndrome.
Ann Rheum Dis
; 78(7): 974-978, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30902822
4.
Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice.
Xenobiotica
; 49(1): 13-21, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29299977
5.
Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.
J Immunol
; 194(8): 3723-34, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25762782
6.
Second generation S1P pathway modulators: research strategies and clinical developments.
Biochim Biophys Acta
; 1841(5): 745-58, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239768
7.
Central Versus Peripheral Drug Exposure Ratio, a Key Differentiator for Siponimod Over Fingolimod?
Neurol Ther
; 12(4): 1187-1203, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37195409
8.
Rationale for Use of Sphingosine-1-Phosphate Receptor Modulators in COVID-19 Patients: Overview of Scientific Evidence.
J Interferon Cytokine Res
; 43(6): 246-256, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36454249
9.
Distribution and efficacy of ofatumumab and ocrelizumab in humanized CD20 mice following subcutaneous or intravenous administration.
Front Immunol
; 13: 814064, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35967378
10.
Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models.
Neurol Neuroimmunol Neuroinflamm
; 9(3)2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35354603
11.
Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights.
Mult Scler J Exp Transl Clin
; 7(4): 20552173211049168, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34777855
12.
Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology.
Front Immunol
; 11: 745, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32425939
13.
Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.
J Med Chem
; 63(23): 14594-14608, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33216547
14.
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.
J Med Chem
; 63(23): 14576-14593, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33252239
15.
Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.
Arthritis Rheumatol
; 72(6): 919-930, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31943941
16.
Reduced cardiac side-effect potential by introduction of polar groups: discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is active in vivo.
Bioorg Med Chem Lett
; 18(6): 2000-5, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18267361
17.
Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism.
PLoS One
; 11(12): e0168252, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-28005953
18.
Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.
Transplantation
; 77(5): 717-26, 2004 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15021835
19.
A simple method to optimize peripheral blood mononuclear cell preparation from cynomolgus monkeys and improve mixed lymphocyte reactions.
J Pharmacol Toxicol Methods
; 50(2): 153-9, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15385090
20.
Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials.
Clin Transl Med
; 3: 36, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25984272