Detalhe da pesquisa
1.
PI3K isoforms in cell signalling and vesicle trafficking.
Nat Rev Mol Cell Biol
; 20(9): 515-534, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31110302
2.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
; 618(7963): 159-168, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225977
3.
The emerging mechanisms of isoform-specific PI3K signalling.
Nat Rev Mol Cell Biol
; 11(5): 329-41, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20379207
4.
Uninephrectomy and class II PI3K-C2ß inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice.
Am J Transplant
; 21(8): 2688-2697, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33370494
5.
A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.
Blood
; 130(18): 2032-2042, 2017 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28903944
6.
Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network.
Nucleic Acids Res
; 45(18): 10466-10480, 2017 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28985358
7.
Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.
Diabetologia
; 59(7): 1503-1512, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27138914
8.
Environmental stress affects the activity of metabolic and growth factor signaling networks and induces autophagy markers in MCF7 breast cancer cells.
Mol Cell Proteomics
; 13(3): 836-48, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24425749
9.
Class III phosphoinositide 3-kinase/VPS34 and dynamin are critical for apical endocytic recycling.
Traffic
; 14(8): 933-48, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23621784
10.
Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection.
Biochem J
; 464(2): e7-10, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25395352
11.
Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover.
Dev Cell
; 57(14): 1694-1711.e7, 2022 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35809565
12.
A new tool to dissect the function of p70 S6 kinase.
Biochem J
; 431(2): e1-3, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20874709
13.
Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation.
Nat Commun
; 12(1): 6409, 2021 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34737295
14.
Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.
Mol Cell Biol
; 27(16): 5746-64, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17562867
15.
Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis.
Thyroid
; 30(1): 133-146, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31650902
16.
Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability.
Biomolecules
; 9(8)2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31374965
17.
Translational deregulation in PDK-1-/- embryonic stem cells.
Mol Cell Biol
; 25(19): 8465-75, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16166629
18.
Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency.
Sci Rep
; 8(1): 14133, 2018 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30237523
19.
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
Nat Commun
; 8(1): 1804, 2017 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180704
20.
Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi.
Biochem J
; 388(Pt 2): 573-83, 2005 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15656792