Detalhe da pesquisa
1.
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.
Acta Neuropathol
; 139(3): 503-526, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31853635
2.
Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo.
J Neurosci
; 38(50): 10595-10606, 2018 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355631
3.
Soluble tau aggregates inhibit synaptic long-term depression and amyloid ß-facilitated LTD in vivo.
Neurobiol Dis
; 127: 582-590, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30910746
4.
Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo.
Neurobiol Dis
; 132: 104582, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31445162
5.
Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.
Alzheimers Dement
; 15(3): 487-496, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30419228
6.
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.
Bioorg Med Chem Lett
; 20(15): 4683-8, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20566291
7.
Anti-PrPC antibody rescues cognition and synapses in transgenic alzheimer mice.
Ann Clin Transl Neurol
; 6(3): 554-574, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30911579
8.
Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways.
Cell Rep
; 22(13): 3612-3624, 2018 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29590627
9.
Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain.
Pain
; 159(3): 550-559, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29351125
10.
TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
EMBO Mol Med
; 9(10): 1366-1378, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28855301
11.
Further validation of LABORAS using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration.
J Neurosci Methods
; 156(1-2): 218-27, 2006 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-16626808
12.
A novel behavioural registration system LABORAS and the social interaction paradigm detect long-term functional deficits following middle cerebral artery occlusion in the rat.
Brain Res
; 1031(1): 118-24, 2005 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15621019
13.
LABORAS: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour.
J Neurosci Methods
; 130(1): 83-92, 2003 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-14583407
14.
High-performance liquid chromatography/tandem mass spectrometry assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates.
J Neurosci Methods
; 137(2): 221-6, 2004 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15262064
15.
Lead discovery for microsomal prostaglandin E synthase using a combination of high-throughput fluorescent-based assays and RapidFire mass spectrometry.
J Biomol Screen
; 17(5): 641-50, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22337655
16.
Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.
J Med Chem
; 52(19): 5785-8, 2009 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19743867