Detalhe da pesquisa
1.
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Hum Mol Genet
; 30(13): 1175-1187, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33601422
2.
Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease.
Pharmacol Res
; 194: 106823, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37336430
3.
SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes.
Brain
; 144(10): 3175-3190, 2021 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33974044
4.
The translational potential of cholesterol-based therapies for neurological disease.
Nat Rev Neurol
; 19(10): 583-598, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37644213
5.
Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington's disease.
J Control Release
; 330: 587-598, 2021 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33412229
6.
Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington's Disease.
ACS Chem Neurosci
; 11(3): 367-372, 2020 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31860272
7.
Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice.
EMBO Mol Med
; 12(10): e12519, 2020 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32959531