Detalhe da pesquisa
1.
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications.
Pharmacol Rev
; 75(2): 263-308, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36549866
2.
Novel avenues of tau research.
Alzheimers Dement
; 20(3): 2240-2261, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38170841
3.
Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases.
J Biol Chem
; 298(1): 101478, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896392
4.
Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges.
Acta Neuropathol
; 145(5): 515-540, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37012443
5.
mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis.
Mov Disord
; 37(4): 778-789, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35040506
6.
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.
Acta Neuropathol
; 142(3): 495-511, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991233
7.
Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity.
FASEB J
; 34(9): 11957-11969, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32701214
8.
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease.
Mol Ther
; 28(4): 1167-1176, 2020 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32087148
9.
The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS.
J Biol Chem
; 294(10): 3501-3513, 2019 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30602569
10.
Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers.
J Am Chem Soc
; 142(40): 17024-17038, 2020 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32926779
11.
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease.
Mol Ther
; 30(11): 3499, 2022 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36261045
12.
Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01.
J Am Chem Soc
; 139(16): 5640-5643, 2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28406616
13.
Preparation of pure populations of covalently stabilized amyloid ß-protein oligomers of specific sizes.
Anal Biochem
; 518: 78-85, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27810329
14.
Correction: Surprising toxicity and assembly behaviour of amyloid ß-protein oxidized to sulfone.
Biochem J
; 478(23): 4151, 2021 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34871366
15.
Correction to: α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.
Acta Neuropathol
; 142(3): 513, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34028589
16.
The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.
Biochemistry
; 54(24): 3729-38, 2015 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26030124
17.
Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.
J Biol Chem
; 289(15): 10727-10737, 2014 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24567327
18.
Exact modeling of cylindrical metal-dielectric multilayers beyond the effective medium approximation.
Opt Lett
; 39(22): 6517-20, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25490508
19.
Tranilast binds to aß monomers and promotes aß fibrillation.
Biochemistry
; 52(23): 3995-4002, 2013 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23679559
20.
Zn2+-Aß40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons.
J Biol Chem
; 287(24): 20555-64, 2012 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22528492