Detalhe da pesquisa
1.
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors.
Bioorg Med Chem Lett
; 25(7): 1597-602, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25736998
2.
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells.
Biochem Biophys Res Commun
; 431(2): 264-9, 2013 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23313490
3.
Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.
Proc Natl Acad Sci U S A
; 107(35): 15529-34, 2010 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-20709959
4.
Fine tuning of the threshold of T cell selection by the Nck adapters.
J Immunol
; 185(12): 7518-26, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078909
5.
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.
Nature
; 440(7085): 818-23, 2006 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16525419
6.
227Th-Labeled Anti-CD22 Antibody (BAY 1862864) in Relapsed/Refractory CD22-Positive Non-Hodgkin Lymphoma: A First-in-Human, Phase I Study.
Cancer Biother Radiopharm
; 36(8): 672-681, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-33887152
7.
First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors.
Cancer Discov
; 11(1): 80-91, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32988960
8.
Nck adaptor proteins control the organization of neuronal circuits important for walking.
Proc Natl Acad Sci U S A
; 104(52): 20973-8, 2007 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18093944
9.
First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors.
Clin Cancer Res
; 26(6): 1237-1246, 2020 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31822497
10.
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading.
J Cell Biol
; 165(4): 493-503, 2004 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15148308
11.
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network.
Mol Cell Biol
; 23(13): 4586-97, 2003 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12808099
12.
The selective c-Met inhibitor tepotinib can overcome epidermal growth factor receptor inhibitor resistance mediated by aberrant c-Met activation in NSCLC models.
Am J Cancer Res
; 7(4): 962-972, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28469968
13.
Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage-Induced Senescence Program in Gastric Cancer.
Clin Cancer Res
; 22(21): 5322-5336, 2016 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27185371
14.
KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells.
Mol Oncol
; 9(7): 1434-46, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25933688
15.
The c-Met Inhibitor MSC2156119J Effectively Inhibits Tumor Growth in Liver Cancer Models.
Cancers (Basel)
; 6(3): 1736-52, 2014 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25256830
16.
The novel ATP-competitive inhibitor of the MET hepatocyte growth factor receptor EMD1214063 displays inhibitory activity against selected MET-mutated variants.
Mol Cancer Ther
; 12(11): 2415-24, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24061647
17.
EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors.
Clin Cancer Res
; 19(11): 2941-51, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23553846
18.
Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma.
Clin Cancer Res
; 15(17): 5445-56, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19706799
19.
Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1.
Proc Natl Acad Sci U S A
; 99(10): 6816-21, 2002 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-11983858
20.
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses.
Nat Immunol
; 4(8): 765-72, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12833154