RESUMO
CARD14-associated papulosquamous eruption (CAPE) is a proposed term that encompasses features ranging from psoriasis to pityriasis rubra pilaris (PRP) in association with CARD14 mutations. The early onset of the disease, prominent facial involvement, family history of an autosomal dominant trait, and poor response to conventional treatment are characteristics of CAPE that distinguish it from classical psoriasis and PRP. We describe the clinical features, family history, and response to therapy in three unrelated children with CAPE and compare these characteristics with those of previously described pediatric patients. Testing for CARD14 mutations in children with early onset of features of psoriasis or pityriasis rubra pilaris and resistance to conventional therapy should be considered.
Assuntos
Exantema , Pitiríase Rubra Pilar , Proteínas Adaptadoras de Sinalização CARD/genética , Criança , Guanilato Ciclase , Humanos , Proteínas de Membrana , Pitiríase Rubra Pilar/diagnóstico , Pitiríase Rubra Pilar/tratamento farmacológico , Pitiríase Rubra Pilar/genéticaRESUMO
Extended treatment for a previous condition provided a key to the diagnosis.