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Due to their highly exposed active sites and high aspect ratio caused by their substantial lateral dimension and thin thickness, two-dimensional (2D) metal-organic framework (MOF) nanosheets are currently considered a potential hybrid material for electrochemical sensing. Herein, we present a nickel-based porphyrinic MOF nanosheet as a versatile and robust platform with an enhanced electrochemical detection performance. It is important to note that the nickel porphyrin ligand reacted with Cu(NO3)2·3H2O in a solvothermal process, with polyvinylpyrrolidone (PVP) acting as the surfactant to control the anisotropic development of creating a 2D Cu-TCPP(Ni) MOF nanosheet structure. To realize the exceptional selectivity, sensitivity, and stability of the synthesized 2D Cu-TCPP(Ni) MOF nanosheet, a laser-induced graphene electrode was modified with the MOF nanosheet and employed as a sensor for the detection of p-nitrophenol (p-NP). With a detection range of 0.5-200 µM for differential pulse voltammetry (DPV) and 0.9-300 µM for cyclic voltammetry (CV), the proposed sensor demonstrated enhanced electrochemical performance, with the limit of detection (LOD) for DPV and CV as 0.1 and 0.3 µM, respectively. The outstanding outcome of the sensor is attributed to the 2D Cu-TCPP(Ni) MOF nanosheet's substantial active surface area, innate catalytic activity, and superior adsorption capacity. Furthermore, it is anticipated that the proposed electrode sensor will make it possible to create high-performance electrochemical sensors for environmental point-of-care testing since it successfully detected p-NP in real sample analysis.
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BACKGROUND: The World Health Organization has proposed that onchocerciasis elimination (interruption) of transmission be verified in 12 (approximately a third) endemic countries by 2030. The strategy to reach this goal is based on ivermectin Mass Drug Administration (MDA) with high geographical and therapeutic coverage. In addition to coverage, high levels of treatment adherence are paramount. We investigated factors associated with ivermectin intake in an area of Ghana with persistent Onchocerca volvulus infection. METHODS: In August 2021, a cross-sectional mixed-methods study was conducted in 13 onchocerciasis-endemic communities in the Bono Region of Ghana. Individuals aged ≥ 10 years were invited to participate in a questionnaire survey. A total of 48 focus group discussions and in-depth interviews with 10 community drug distributors and 13 community leaders were conducted. RESULTS: A total of 510 people participated in the study [median age: 32, interquartile range 30 (20â50) years]; 274 (53.7%) were females. Of the total, 320 (62.7%) declared that they adhered to each treatment round and 190 (37.3%) admitted they had not taken ivermectin during at least one MDA round, since becoming eligible for treatment. Of 483 participants with complete information, 139 (28.8%) did not take ivermectin during the last round (March 2021), and 24 (5.0%) had never taken ivermectin (systematic non-adherers). Reasons for not taking ivermectin included previous experience/fear of side-effects, being absent during MDA, pregnancy, the desire to drink alcohol, and drug distribution challenges. Being male, having good knowledge and perception of the disease, and not having secondary or higher level of formal education were significantly associated with higher odds of ivermectin intake. CONCLUSIONS: A relatively high level of non-adherence to ivermectin treatment was documented. There is a need for targeted educational and behavioural change campaigns to reverse these trends and ensure a steady course toward meeting onchocerciasis elimination targets in Ghana.
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Ivermectina , Oncocercose , Adulto , Feminino , Humanos , Masculino , Estudos Transversais , Gana/epidemiologia , Ivermectina/uso terapêutico , Oncocercose/tratamento farmacológico , Oncocercose/epidemiologia , Infecção Persistente , Adesão à MedicaçãoRESUMO
Organic pollutants (OPs) have garnered a considerable amount of attention in recent times due to their extreme toxicity toward humans and the ecosystem. The need for an inexpensive yet robust, sensitive, selective, and easy-to-operate method for detecting OPs remains a challenge. Herein, a portable electrochemical sensor is proposed based on manganese porphyrin-functionalized carbon cloth (CC). To explain the electrochemical performance of the sensor, cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were employed. The presence of manganese(III) ion in the center of the porphyrin ligand acted as an agent for the transfer of electrons and enhanced sensitivity toward analyte-specific redox catalysis. Moreover, it allowed for the concurrent detection of multiple analytes in a complex environment. The modified CC electrode can selectively detect nitroaromatic and phenolic compounds with accessible data collected through wireless means onto a smartphone device. The as-synthesized electrode demonstrated a higher sensitivity toward the detection of nitrobenzene (NB) and aqueous phenol with a limit of detection (LOD) found to be 5.9268 × 10-10 M and 4.0178 × 10-10 M, respectively. Additionally, our proposed portable electrochemical sensor demonstrates a high selectivity and reproducibility toward nitroaromatic and phenolic compounds, which can be employed in real complex water samples. With regard to the sensor's remarkable electrochemical performance, it is envisaged that such a sensor could pave the way for environmental point of care (POC) testing.
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Poluentes Ambientais , Porfirinas , Carbono , Ecossistema , Técnicas Eletroquímicas , Eletrodos , Gases , Humanos , Ligantes , Manganês , Nitrobenzenos , Fenol , Fenóis , Reprodutibilidade dos Testes , ÁguaRESUMO
[This corrects the article DOI: 10.3389/fbioe.2021.797067.].
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The conversion of diverse polymeric substrates into laser-induced graphene (LIG) has recently emerged as a single-step method for the fabrication of patterned graphene-based wearable electronics with a wide range of applications in sensing, actuation, and energy storage. Laser-induced pyrolysis technology has many advantages over traditional graphene design: eco-friendly, designable patterning, roll-to-roll production, and controllable morphology. In this work, we designed wearable and flexible graphene-based strain and pressure sensors by laminating LIG from a commercial polyimide (PI) film. The as-prepared LIG was transferred onto a thin polydimethylsiloxane (PDMS) sheet, interwoven inside an elastic cotton sports fabric with the fabric glue as a wearable sensor. The single LIG/PDMS layer acts as a strain sensor, and a two-layer perpendicular stacking of LIG/PDMS (x and y laser-directed films) is designed for pressure sensing. This newly designed graphene textile (IGT) sensor performs four functions in volleyball sportswear, including volleyball reception detection, finger touch foul detection during blocking the ball from an opponent player, spike force measurements, and player position monitoring. An inexpensive sensor assists athletes in training and helps the coach formulate competition strategies.
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Grafite , Humanos , Eletrônica , LasersRESUMO
In the face of complex environments, considerable effort has been made to accomplish sensitive, accurate and highly-effective detection of target analytes. Given the versatility of metal clusters and ligands, high porosity and large specific surface area, metal-organic framework (MOF) provides researchers with prospective solutions for the construction of biosensing platforms. Combined with the benefits of electrochemistry method such as fast response, low cost and simple operation, the untapped applications of MOF for biosensors are worthy to be exploited. Therefore, this review briefly summarizes the preparation methods of electroactive MOF, including synthesize with electroactive ligands/metal ions, functionalization of MOF with biomolecules and modification for MOF composites. Moreover, recent biosensing applications are highlighted in terms of small biomolecules, biomacromolecules, and pathogenic cells. We conclude with a discussion of future challenges and prospects in the field. It aims to offer researchers inspiration to address the issues appropriately in further investigations.