Detalhe da pesquisa
1.
Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2.
PLoS Pathog
; 19(8): e1011328, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37549173
2.
A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models.
J Pharmacol Exp Ther
; 371(2): 231-241, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31406003
3.
C5A Protects Macaques from Vaginal Simian-Human Immunodeficiency Virus Challenge.
Antimicrob Agents Chemother
; 60(1): 693-8, 2016 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26552985
4.
Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production.
Gastroenterology
; 148(2): 403-14.e7, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25305505
5.
Cyclophilin and NS5A inhibitors, but not other anti-hepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factories.
Antimicrob Agents Chemother
; 59(5): 2496-507, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25666154
6.
Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide.
Antimicrob Agents Chemother
; 58(2): 687-97, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24217696
7.
Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model.
PLoS One
; 19(3): e0298211, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38427624
8.
Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH.
PLoS One
; 19(4): e0301711, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38573968
9.
HCV NS5A and IRF9 compete for CypA binding.
J Hepatol
; 58(1): 16-23, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22902549
10.
The Cyclophilin Inhibitor Rencofilstat Decreases HCV-induced Hepatocellular Carcinoma Independently of Its Antiviral Activity.
bioRxiv
; 2023 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37645728
11.
The Cyclophilin Inhibitor Rencofilstat Decreases HCV-Induced Hepatocellular Carcinoma Independently of Its Antiviral Activity.
Viruses
; 15(10)2023 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37896876
12.
PD 404,182 is a virocidal small molecule that disrupts hepatitis C virus and human immunodeficiency virus.
Antimicrob Agents Chemother
; 56(2): 672-81, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22083468
13.
The cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A complexes.
Antimicrob Agents Chemother
; 56(7): 3888-97, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22585215
14.
Sublimable C5A delivery provides sustained and prolonged anti-HIV microbicidal activities.
Antimicrob Agents Chemother
; 56(6): 3336-43, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22430971
15.
Multiple mutations in hepatitis C virus NS5A domain II are required to confer a significant level of resistance to alisporivir.
Antimicrob Agents Chemother
; 56(10): 5113-21, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22802259
16.
Sustained local delivery of structurally diverse HIV-1 microbicides released from sublimation enthalpy controlled matrices.
Pharm Res
; 29(11): 3156-68, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22736232
17.
Early SARS-CoV-2 dynamics and immune responses in unvaccinated participants of an intensely sampled longitudinal surveillance study.
Commun Med (Lond)
; 2: 129, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36238348
18.
Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family.
Antimicrob Agents Chemother
; 55(5): 1975-81, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21383094
19.
Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus.
Proc Natl Acad Sci U S A
; 105(14): 5525-30, 2008 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18378908
20.
The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance.
PLoS One
; 16(5): e0251934, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34014993