Detalhe da pesquisa
1.
Kinetic and Structural Characterization of a Flavin-Dependent Putrescine N-Hydroxylase from Acinetobacter baumannii.
Biochemistry
; 61(22): 2607-2620, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36314559
2.
Structure-affinity relationships of reversible proline analog inhibitors targeting proline dehydrogenase.
Org Biomol Chem
; 20(4): 895-905, 2022 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35018940
3.
In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1.
J Biol Chem
; 295(52): 18316-18327, 2020 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33109600
4.
Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-γ-semialdehyde dehydrogenase active site of bifunctional proline utilization A.
Arch Biochem Biophys
; 698: 108727, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33333077
5.
Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target.
Amino Acids
; 53(12): 1817-1834, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34003320
6.
Structure-based engineering of minimal proline dehydrogenase domains for inhibitor discovery.
Protein Eng Des Sel
; 352022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36448708
7.
Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans-4-hydroxy-L-proline.
Protein Sci
; 30(8): 1714-1722, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34048122
8.
Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles.
ACS Chem Biol
; 16(11): 2268-2279, 2021 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34542291