Detalhe da pesquisa
1.
Role of calcium-independent phospholipase A(2)ß in human pancreatic islet ß-cell apoptosis.
Am J Physiol Endocrinol Metab
; 303(11): E1386-95, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23074238
2.
Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1.
J Biol Chem
; 285(9): 6693-705, 2010 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20032468
3.
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine.
Arterioscler Thromb Vasc Biol
; 27(3): 690-6, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17185615
4.
Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations.
Biochim Biophys Acta
; 1580(1): 40-56, 2002 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-11923099
5.
Evidence of contribution of iPLA2ß-mediated events during islet ß-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2ß in T1D development.
Endocrinology
; 155(9): 3352-64, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25004092
6.
Genetic modulation of islet ß-cell iPLA2ß expression provides evidence for its impact on ß-cell apoptosis and autophagy.
Islets
; 5(1): 29-44, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23411472
7.
Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.
J Biol Chem
; 283(50): 34819-32, 2008 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18936091
8.
Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.
Am J Physiol Endocrinol Metab
; 294(2): E217-29, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17895289
9.
The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
Biochemistry
; 46(35): 10170-85, 2007 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17685585
10.
Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.
J Biol Chem
; 282(37): 27100-27114, 2007 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17627946
11.
Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells.
J Biol Chem
; 281(1): 187-98, 2006 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16286468
12.
Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.
J Biol Chem
; 281(30): 20958-20973, 2006 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16732058
13.
Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.
Biochemistry
; 43(4): 918-30, 2004 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-14744135