Detalhe da pesquisa
1.
Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents.
Drug Dev Res
; 81(2): 215-231, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31471933
2.
Propargylamine-derived multitarget-directed ligands: fighting Alzheimer's disease with monoamine oxidase inhibitors.
J Neural Transm (Vienna)
; 120(6): 893-902, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23238976
3.
A comparison between radiometric and fluorimetric methods for measuring SSAO activity.
J Neural Transm (Vienna)
; 120(6): 1015-8, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23400361
4.
A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.
J Neural Transm (Vienna)
; 120(6): 911-8, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23263540
5.
Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome.
Elife
; 82019 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31403401
6.
Sodium bicarbonate enhances membrane-bound and soluble human semicarbazide-sensitive amine oxidase activity in vitro.
J Biochem
; 142(5): 571-6, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17846062
7.
Loss of Mitochondrial Ndufs4 in Striatal Medium Spiny Neurons Mediates Progressive Motor Impairment in a Mouse Model of Leigh Syndrome.
Front Mol Neurosci
; 10: 265, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28883788
8.
ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.
Front Neurosci
; 10: 294, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27445665
9.
Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease.
Front Neurosci
; 10: 205, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27252617
10.
Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases.
Front Neurosci
; 10: 541, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27932945
11.
Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids.
Food Funct
; 6(4): 1251-60, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25756794
12.
Imaging of mitochondrial dynamics in motor and sensory axons of living mice.
Methods Enzymol
; 547: 97-110, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25416354
13.
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Eur J Med Chem
; 75: 82-95, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24530494
14.
Neuroprotective effects of the MAO-B inhibitor, PF9601N, in an in vivo model of excitotoxicity.
CNS Neurosci Ther
; 20(7): 641-50, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24767579
15.
Multipotent, permeable drug ASS234 inhibits Aß aggregation, possesses antioxidant properties and protects from Aß-induced apoptosis in vitro.
Curr Alzheimer Res
; 10(8): 797-808, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23919774
16.
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Eur J Med Chem
; 52: 251-62, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22503231
17.
LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease.
Behav Brain Res
; 228(2): 261-71, 2012 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119712
18.
Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.
Eur J Med Chem
; 46(9): 4665-8, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21669479
19.
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
J Med Chem
; 54(24): 8251-70, 2011 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22023459
20.
A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain.
J Alzheimers Dis
; 18(4): 849-65, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19661617