Detalhe da pesquisa
1.
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
PLoS Biol
; 20(5): e3001621, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507910
2.
Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes.
Proc Natl Acad Sci U S A
; 119(43): e2205492119, 2022 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36256825
3.
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
PLoS Biol
; 19(12): e3001480, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34914695
4.
Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.
Neurobiol Dis
; 170: 105769, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35580815
5.
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.
Brain
; 143(1): 234-248, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31755958
6.
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease.
Mov Disord
; 34(4): 460-468, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30675927
7.
Bcl-xL-mediated antioxidant function abrogates the disruption of mitochondrial dynamics induced by LRRK2 inhibition.
Biochim Biophys Acta
; 1862(1): 20-31, 2016 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26435084
8.
On the mechanism underlying ethanol-induced mitochondrial dynamic disruption and autophagy response.
Biochim Biophys Acta
; 1852(7): 1400-9, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25779081
9.
Structure and regulation of full-length human leucine-rich repeat kinase 1.
Nat Commun
; 14(1): 4797, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558661
10.
Make dopamine neurons great again: An exciting new therapeutic option in parkinson's disease.
Mov Disord
; 32(8): 1164, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28631854
11.
The endoplasmic reticulum contributes to lysosomal tubulation/sorting driven by LRRK2.
Mol Biol Cell
; 33(13): ar124, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36044336
12.
LRRK2 recruitment, activity, and function in organelles.
FEBS J
; 289(22): 6871-6890, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34196120
13.
Activating Transcription Factor 3 (ATF3) Protects Retinal Ganglion Cells and Promotes Functional Preservation After Optic Nerve Crush.
Invest Ophthalmol Vis Sci
; 61(2): 31, 2020 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32084268
14.
LRRK2 mediates tubulation and vesicle sorting from lysosomes.
Sci Adv
; 6(46)2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33177079
15.
The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
Cell Rep
; 31(5): 107614, 2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32375042
16.
The role of Rab GTPases in the pathobiology of Parkinson' disease.
Curr Opin Cell Biol
; 59: 73-80, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31054512
17.
Rotenone Induces the Formation of 4-Hydroxynonenal Aggresomes. Role of ROS-Mediated Tubulin Hyperacetylation and Autophagic Flux Disruption.
Mol Neurobiol
; 53(9): 6194-6208, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26558631
18.
Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.
J Clin Invest
; 126(12): 4659-4673, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27841758
19.
CYP2E1 in the Human Retinal Pigment Epithelium: Expression, Activity, and Induction by Ethanol.
Invest Ophthalmol Vis Sci
; 56(11): 6855-63, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26567798
20.
Halting progressive neurodegeneration in advanced retinitis pigmentosa.
J Clin Invest
; 125(9): 3704-13, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26301813