Detalhe da pesquisa
1.
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Nature
; 615(7953): 678-686, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922586
2.
A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Nature
; 598(7881): 504-509, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34616043
3.
Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Nature
; 599(7883): E2, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34671169
4.
Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.
J Med Chem
; 67(5): 4063-4082, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38482827
5.
Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics.
J Org Chem
; 78(2): 212-23, 2013 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23227990
6.
Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein.
Proc Natl Acad Sci U S A
; 107(1): 308-13, 2010 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19966279
7.
Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.
J Med Chem
; 66(13): 8808-8821, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37389813
8.
From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.
ACS Med Chem Lett
; 13(12): 1879-1884, 2022 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36518706
9.
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 19(9): 2492-6, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19342234
10.
1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.
Antimicrob Agents Chemother
; 52(12): 4420-31, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18852280
11.
Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121).
J Med Chem
; 51(4): 875-96, 2008 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18254606
12.
Selection of a respiratory syncytial virus fusion inhibitor clinical candidate, part 1: improving the pharmacokinetic profile using the structure-property relationship.
J Med Chem
; 50(19): 4572-84, 2007 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17722899
13.
Toward the Synthesis of Fluorinated Analogues of HCV NS3/4A Serine Protease Inhibitors Using Methyl α-Amino-ß-fluoro-ß-vinylcyclopropanecarboxylate as Key Intermediate.
Org Lett
; 17(12): 2968-71, 2015 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26053226
14.
Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model.
PLoS One
; 10(5): e0126959, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26010881
15.
Development of a high-throughput antiviral assay for screening inhibitors of chikungunya virus and generation of drug-resistant mutations in cultured cells.
Methods Mol Biol
; 1030: 429-38, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23821286
16.
Palladium catalyzed one-pot sequential Suzuki cross-coupling-direct C-H functionalization of imidazo[1,2-a]pyrazines.
Org Lett
; 14(23): 6012-5, 2012 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23151283
17.
Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection.
Curr Opin Drug Discov Devel
; 12(4): 479-87, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19562644