Detalhe da pesquisa
1.
Scientific and Regulatory Policy Committee Points to Consider: Fixation, Trimming, and Sectioning of Nonrodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies.
Toxicol Pathol
; 50(2): 235-251, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34693851
2.
Inflammation of a Posterior Ciliary Artery in a Naive Cynomolgus Macaque.
Toxicol Pathol
; 49(3): 602-604, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32856568
3.
Foreign Body Reaction, Retinal Degeneration, and Epiretinal Membranes Associated With Intravitreal Administration of PLGA Rods.
Toxicol Pathol
; 49(3): 656-662, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32975492
4.
Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy.
Toxicol Pathol
; 49(3): 610-620, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33297886
5.
Intravitreal Administration of Acetyl Triethyl Citrate and Benzyl Benzoate Is Retinotoxic in Rabbits but Not in Cynomolgus Monkeys.
Toxicol Pathol
; 49(3): 621-633, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33252011
6.
Nonclinical Toxicology and Biocompatibility Program Supporting Clinical Development and Registration of the Port Delivery System With Ranibizumab for Neovascular Age-Related Macular Degeneration.
Toxicol Pathol
; 49(3): 663-672, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33205714
7.
EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL.
Retina
; 40(8): 1520-1528, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31436674
8.
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Regul Toxicol Pharmacol
; 113: 104624, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32126256
9.
The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice.
Hum Mol Genet
; 23(7): 1842-55, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24234655
10.
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
J Med Chem
; 67(5): 3287-3306, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38431835
11.
Intravitreal RTH258 (brolucizumab) demonstrates no effect on pregnancy, parturition, embryofetal or postnatal development in cynomolgus monkeys.
Reprod Toxicol
; 121: 108468, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37666285
12.
CSL-Tox: an open-source analytical framework for the comparison of short-term and long-term toxicity end points and assessing the need of chronic studies in drug development.
Sci Rep
; 13(1): 14865, 2023 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37684321
13.
International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs.
Clin Transl Sci
; 16(5): 723-741, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36651217
14.
Conjunctival bacterial and fungal flora in healthy horses in the UK.
Vet Ophthalmol
; 14(3): 195-9, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21521444
15.
Uncovering of intraspecies macular heterogeneity in cynomolgus monkeys using hybrid machine learning optical coherence tomography image segmentation.
Sci Rep
; 11(1): 20647, 2021 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34667265
16.
An Anti-CD22-seco-CBI-Dimer Antibody-Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models.
Mol Cancer Ther
; 20(2): 340-346, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33273056
17.
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Sci Transl Med
; 13(593)2021 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33980574
18.
Ectopic thyroid in the aortic valve of a Han Wistar rat.
Toxicol Pathol
; 38(2): 312-4, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20100844
19.
Retinal Features in Cynomolgus Macaques (Macaca fascicularis) Assessed by Using Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography.
Comp Med
; 70(2): 145-151, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32164796
20.
Determination of a No Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Cynomolgus Monkeys.
J Ocul Pharmacol Ther
; 35(4): 245-253, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30964386