Detalhe da pesquisa
1.
Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling.
Bioorg Med Chem
; 28(3): 115262, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31882369
2.
Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
Synapse
; 69(2): 78-85, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25382408
3.
Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors.
Bioorg Med Chem
; 23(7): 1588-600, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25703249
4.
A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses.
J Pharmacol Exp Ther
; 349(2): 310-8, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24563531
5.
Development of 2-Aminotetralin-Type Serotonin 5-HT1 Agonists: Molecular Determinants for Selective Binding and Signaling at 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT1F Receptors.
ACS Chem Neurosci
; 15(2): 357-370, 2024 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38150333
6.
Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands.
J Pharmacol Exp Ther
; 347(3): 705-16, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24080681
7.
Oxycodone self-administration and reinstatement in male and female squirrel monkeys: Effects of alternative reinforcer availability.
bioRxiv
; 2023 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711610
8.
Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Receptors.
ACS Chem Neurosci
; 14(10): 1884-1895, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37104867
9.
Effects of (-)-MBP, a novel 5-HT2C agonist and 5-HT2A/2B antagonist/inverse agonist on brain activity: A phMRI study on awake mice.
Pharmacol Res Perspect
; 11(5): e01144, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37837184
10.
"Selective" serotonin 5-HT2A receptor antagonists.
Biochem Pharmacol
; 200: 115028, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35381208
11.
FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice.
ACS Chem Neurosci
; 13(24): 3629-3640, 2022 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36473166
12.
A new class of 5-HT2A /5-HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2-aminotetralins.
Br J Pharmacol
; 179(11): 2610-2630, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34837227
13.
A novel potential therapeutic avenue for autism: design, synthesis and pharmacophore generation of SSRIs with dual action.
Bioorg Med Chem Lett
; 21(22): 6714-23, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21982496
14.
Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice.
Epilepsy Res
; 175: 106677, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34130255
15.
(S)-5-(2'-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder.
ACS Pharmacol Transl Sci
; 3(3): 509-523, 2020 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32566916
16.
New Approach to 4-Phenyl-ß-aminotetralin from 4-(3-Halophenyl)tetralen-2-ol Phenylacetate.
Tetrahedron Lett
; 50(36): 5107-5109, 2009 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20161011
17.
Ligand-directed serotonin 5-HT2C receptor desensitization and sensitization.
Eur J Pharmacol
; 848: 131-139, 2019 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30689993
18.
Effect of (-)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice.
Pharmacol Biochem Behav
; 91(1): 176-80, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18692085
19.
Mutagenesis Analysis Reveals Distinct Amino Acids of the Human Serotonin 5-HT2C Receptor Underlying the Pharmacology of Distinct Ligands.
ACS Chem Neurosci
; 8(1): 28-39, 2017 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27580242
20.
Role of PKA and PKC in histamine H1 receptor-mediated activation of catecholamine neurotransmitter synthesis.
Neurosci Lett
; 407(3): 249-53, 2006 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-16978782