RESUMO
OBJECTIVE: The present study is aimed at performing the molecular characterization of a Tunisian family with piebaldism. METHODS: As the proband and her mother showed a severe phenotype, we first chose to screen exons 10, 11, 12, 13, 16, 17 and 18 of the KIT proto-oncogene by direct sequencing. RESULTS: Direct sequencing analysis showed a C to T substitution at 1939 in exon 13 (c.1939C>T) in heterozygous state in the patient and her mother. The mutation was not found in their unaffected family members or normal controls. CONCLUSION: Our results provide additional support that mutations in the tyrosine kinase domain of the KIT gene are responsible for the severe form of piebaldism.
Assuntos
Mutação de Sentido Incorreto , Piebaldismo/genética , Mutação Puntual , Proteínas Proto-Oncogênicas c-kit/genética , Substituição de Aminoácidos , Domínio Catalítico , Éxons/genética , Feminino , Humanos , Lactente , Masculino , Fenótipo , Estrutura Terciária de Proteína , Proto-Oncogene Mas , Análise de Sequência de DNA , TunísiaRESUMO
AIM OF STUDY: Recombination is one of the major mechanisms of evolution in poliovirus. In this work, recombination was assessed in children during vaccination with OPV and among circulating vaccine strains isolated in Tunisia during the last 15 years in order to identify a possible role of recombination in the response to the vaccine or the acquisition of an increased transmissibility. MATERIAL AND METHODS: This study included 250 poliovirus isolates: 137 vaccine isolates, excreted by children during primary vaccination with OPV and 113 isolates obtained from acute flaccid paralytic (AFP) cases and healthy contacts. Recombination was first assessed using a double PCR-RFLP, and sequencing. RESULTS: Nineteen per cent of recombinant strains were identified: 20% of strains excreted by vaccinees among 18% of circulating strains. The proportion of recombinant in isolates of serotype1 was very low in the two groups while the proportions of recombinants in serotypes 2 and 3 were different. In vaccinees, the frequency of recombinants in serotype3 decreased during the course of vaccination: 54% after the first dose, 32% after the second and 14% after the third dose. CONCLUSION: These results suggest that recombination enhances the ability of serotype3 vaccine strains to induce an immune response. Apart from recent vaccination, it may contribute to a more effective transmissibility of vaccine strains among human population.
Assuntos
Vacina Antipólio Oral , Poliovirus/genética , RNA Viral/genética , Vírus Reordenados/genética , Recombinação Genética , Eliminação de Partículas Virais , Administração Oral , Humanos , Lactente , Recém-Nascido , Hipotonia Muscular , Paralisia/epidemiologia , Paralisia/etiologia , Paralisia/virologia , Poliomielite/epidemiologia , Poliomielite/virologia , Poliovirus/classificação , Poliovirus/isolamento & purificação , Reação em Cadeia da Polimerase , Polimorfismo de Fragmento de Restrição , Vírus Reordenados/isolamento & purificação , Sorotipagem , Especificidade da Espécie , Tunísia/epidemiologia , Urina/virologia , Vacinação , Vacinas Atenuadas , Eliminação de Partículas Virais/genéticaRESUMO
Xeroderma pigmentosum (XP, OMIM 278700-278780) is a group of autosomal recessive diseases characterized by hypersensitivity to UV rays. There are seven complementation groups of XP (XPA to XPG) and XPV. Among them, the XP group C (XP-C) is the most prevalent type in Western Europe and in the United States. We report here on the clinical and genetic investigation of XP-C patients in 14 Tunisian families. As the XPC V548A fs X572 mutation has been identified in Algerian and Moroccan populations, Tunisian patients were first screened for this mutation by a direct sequencing of exon 9 of the XPC gene. All patients with a severe clinical form had this mutation, thus showing the homogeneity of the mutational spectrum of XPC in Tunisia. A potential founder effect was searched and confirmed by haplotype analysis. Taking into account the similarity of the genetic background, we propose a direct screening of this mutation as a rapid and cost-effective tool for the diagnosis of XP-C in North Africa.
Assuntos
Substituição de Aminoácidos/genética , Proteínas de Ligação a DNA/genética , Mutação da Fase de Leitura/genética , Xeroderma Pigmentoso/diagnóstico , Xeroderma Pigmentoso/genética , Adolescente , Adulto , Sequência de Bases , Criança , Pré-Escolar , Análise Mutacional de DNA , Feminino , Haplótipos , Humanos , Masculino , Dados de Sequência Molecular , Linhagem , Tunísia , Adulto JovemRESUMO
BACKGROUND: Darier's disease (OMIM 124200) is an autosomal-dominant skin disorder characterized by warty papules and plaques in seborreheic areas, palmo-plantar pits and distinctive nail abnormalities. The disease has complete penetrance in adults and variable expressivity. It is caused by mutations in the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca(2+) ATPase type 2 isoform (SERCA2). OBJECTIVE: We report histological investigations of six unrelated Tunisian families including 15 affected individuals with Darier's disease mutations. RESULTS: The typical histological features of Darier's disease have been observed in the 15 patients. Variable histological features have been observed among Tunisian patients ranging from mild to moderate lesions of Darier's disease. A significant correlation has been observed between the clinical presentation of the Darier's disease (mild or moderate) and the intensity of the histological features. Isolated acral form of Darier's disease was seen in one case. Two distinct original associations have been observed: Darier's disease/pemphigus vulgaris in one patient and Darier's disease/ichtyosis in the other patient. CONCLUSION: Our findings confirmed the clinical heterogeneity of Darier's disease on the basis of histological study. The intensity of the histological features could be closely correlated to the severity of Darier's disease clinical presentation.
Assuntos
Doença de Darier/patologia , Doença de Darier/genética , Feminino , Humanos , Masculino , Mutação , ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/genética , Índice de Gravidade de Doença , TunísiaRESUMO
BACKGROUND: Genetic characterisation of polioviruses remains highly important even in countries where wild poliovirus circulation has been interrupted. Sequence data on representative wild strains from all geographical regions is required for surveillance purposes and surveillance for vaccine-related isolates with increased potential for transmissibility in humans should continue. OBJECTIVE: To report the genetic characteristics of wild and vaccine-related polioviruses isolated in Tunisia from 1991 to 2006. STUDY DESIGN: Wild isolates were sequenced in the VP1 genomic region and compared to each other. Vaccine-related isolates were assessed for genetic recombination by PCR/RFLP and sequence analysis of the 3D region. Recombinant viruses were assessed for genetic drift in the VP1 region. RESULTS: The VP1 sequences of the last wild isolates, all from serotype3, showed 97.7-98.7% nucleotide homology. Nineteen percent of vaccine-related isolates were vaccine/vaccine intertypic recombinants. No recombinant with non-poliovirus enteroviruses was identified. Mutational differences in the VP1 sequences of recombinant viruses ranged from 0.0% to 0.7% indicating a limited replication period. CONCLUSIONS: This study provides sequence data on wild polioviruses from Tunisia/North Africa and shows that in countries with continuous high vaccine coverage transmission of vaccine-related polioviruses is time-limited.
Assuntos
Poliomielite/epidemiologia , Poliomielite/virologia , Vacina Antipólio Oral , Poliovirus , Recombinação Genética , Animais , Proteínas do Capsídeo/genética , Linhagem Celular , Deriva Genética , Genoma Viral , Humanos , Camundongos , Dados de Sequência Molecular , Poliovirus/classificação , Poliovirus/genética , Poliovirus/isolamento & purificação , Reação em Cadeia da Polimerase , Polimorfismo de Fragmento de Restrição , Análise de Sequência de DNA , Tunísia/epidemiologiaRESUMO
BACKGROUND: Lichen planus is an inflammatory dermatosis involving either skin and/or mucosal epithelial surfaces. A cell-mediated cytotoxicity response is the main suspected mechanism of this dermatosis. Granzyme B and granulysin are components of the cytoplasmic granules of cytotoxic T lymphocytes and natural killers. They are involved in cell-mediated apoptosis. This work studies the possible implication of granzyme B and granulysin in the cell-mediated cytotoxicity response in lichen planus. METHODS: In situ expression of granzyme B and granulysin was studied by real-time reverse transcriptase polymerase chain reaction in 15 biopsies of lichen planus. The distribution and the phenotype of the inflammatory infiltrate and the expression of granzyme B were studied by immunohistochemistry in seven other biopsies of lichen planus. RESULTS: Granzyme B and granulysin mRNA expression was one to two hundred times greater than in biopsies of normal skin. Immunohistochemical study revealed that the lymphohistiocytic infiltrate consisted mainly of CD4+ and CD8+ lymphocytes. Granzyme B+ cells were observed close to apoptotic keratinocytes. CONCLUSION: Our results suggest a central role for cell-mediated cytotoxicity by the granule exocytosis pathway probably because of auto-cytotoxic T-cell clones in the pathogenesis of lichen planus.
Assuntos
Antígenos de Diferenciação de Linfócitos T/metabolismo , Granzimas/metabolismo , Líquen Plano/metabolismo , Adolescente , Adulto , Antígenos CD/metabolismo , Antígenos de Diferenciação de Linfócitos T/genética , Apoptose/imunologia , Criança , Feminino , Granzimas/genética , Humanos , Imuno-Histoquímica , Imunofenotipagem , Líquen Plano/imunologia , Líquen Plano/patologia , Masculino , Pessoa de Meia-Idade , RNA Mensageiro/análise , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Pele/patologia , Estatísticas não Paramétricas , Linfócitos T Citotóxicos/metabolismoRESUMO
Supernumerary nipples (SNs) or polythelia are developmental abnormalities of breast tissue. They are located along the embryonic mammary lines. Polythelia usually occurs as a sporadic abnormality, although familial aggregation has been occasionally reported. Hailey-Hailey disease is a rare autosomal genodermatosis characterized by disturbed keratinocyte adhesion. These cutaneous disorders have been described in correlation with many other abnormalities. We report here the association of Hailey-Hailey disease and supernumerary nipples in a Northern Tunisian family. To our knowledge, this is the first report of such a clinical association.
Assuntos
Mamilos/anormalidades , Pênfigo Familiar Benigno/complicações , Adulto , Mama , Feminino , Genes Dominantes , Humanos , Pessoa de Meia-Idade , Linhagem , Pênfigo Familiar Benigno/genética , Pênfigo Familiar Benigno/patologia , Pele/patologiaRESUMO
Detection of enterovirus genome by PCR in clinical samples is now extensively used for the diagnostic of enterovirus infections given its rapidity and high sensitivity. In contrast, its use in surveillance programs targeting specific enterovirus serotypes remains less frequent. The most sensitive protocols are those amplifying in the 5'untranslated region (5'UTR). However the possibility to use sequence analysis of the 5'UTR amplicons for serotype identification is not yet well established. In this report, stool samples from polio suspected cases and their healthy contacts were tested. The results of direct detection of enterovirus genome by PCR and serotype identification based on sequence analysis of the PCR products in the 5'UTR were compared to those of standard cell-culture-based protocols. Standard protocols detected enterovirus isolates in 7.4% of cases while 9.8% of samples were positive by PCR. Serotype identification based on sequence analysis of amplicons showed concordant results with serotypes determined on virus isolates by seroneutralisation or sequencing in the VP1 gene in 39% of cases only. These results confirm that the use of PCR amplification from stool samples improves the sensitivity of enterovirus detection but do not recommend the use of sequence analysis of the 5'UTR PCR product to determine enterovirus serotype.
Assuntos
Regiões 5' não Traduzidas/genética , Infecções por Enterovirus/virologia , Enterovirus/genética , Fezes/virologia , Reação em Cadeia da Polimerase/métodos , RNA Viral/genética , Estudos de Casos e Controles , Enterovirus/classificação , Infecções por Enterovirus/diagnóstico , Infecções por Enterovirus/epidemiologia , Genoma Viral/genética , Humanos , Epidemiologia Molecular , Poliomielite/epidemiologia , Poliomielite/virologia , Poliovirus/genética , Vigilância da População , Sensibilidade e Especificidade , Sorotipagem , Tunísia/epidemiologia , Cultura de Vírus/métodosRESUMO
The aim of the study is to evaluate the prevalence of specific antibodies anti-human parvovirus B19 (PVB19) immunoglobulin M (IgM) and IgG in children with fever and rash. This study involved 257 children aged from 7 months to 15 years with febrile rash unrelated to measles and rubella (seronegative for IgM). The sera were examined by immunoenzymatic assay. Detection of antibodies of PVB19 was done by enzyme-linked immunosorbent assay (Elisa). In our study, prevalence of immunoglobulin G (IgG) and IgM were 44 and 11.3%, respectively. Clinically, children with positive IgM serology had submitted an erythema infectiosum (13/29 cases), myocarditis (1 case), encephalitis (1 case), severe sickle cell anemia (7 cases), and immunocompromised (7 cases). The incidence rate of viral infection was 11.3%; most of the cases of PVB19 infection occurred between the months of May and August. Incidence was higher in the 10-15 years age group (21%). The prevalence of IgG antibody varied and increased with age, it rises from 38.2% in preschool children (19 months-4 years) to 53.5% in those aged between 4.5 and 15 years, reaching 58% in the 10-15 years age group. The four risk factors of PVB19 infection are: (1) those aged between 4.5 and 9 years, which is the most affected age group (P = 0.0018); (2) female gender in children aged between 19 months and 4 years (P = 0.037); (3) transfusion and (4) immune deficiency (P = 0.022 and P = 0.001, respectively). The study of the prevalence of PVB19 infection shows that viral infection is acquired early in childhood, increases with age; viral transmission is favored by the community life. Because of the widespread vaccination program against measles and rubella, the systematic search of PVB19 in front of eruptive fevers becomes important.
Assuntos
Eritema Infeccioso/epidemiologia , Exantema/epidemiologia , Febre/epidemiologia , Parvovirus B19 Humano/isolamento & purificação , Adolescente , Anticorpos Antivirais/sangue , Criança , Pré-Escolar , Ensaio de Imunoadsorção Enzimática , Eritema Infeccioso/sangue , Eritema Infeccioso/complicações , Exantema/sangue , Exantema/virologia , Feminino , Febre/sangue , Febre/virologia , Humanos , Imunoglobulina G , Lactente , Masculino , Parvovirus B19 Humano/imunologia , Estudos Soroepidemiológicos , Tunísia/epidemiologiaRESUMO
Toll-like receptor 9 (TLR9) plays a major role in the fight against DNA viruses infections. Despite its antitumor properties, inappropriate activation of TLR9 during chronic inflammation may cause the activation of transcription factors inducing pro-cancerous activities. Thus, the relationship between TLR9 and cancer remains highly confrontational especially in gynecological cancers and cervical cancer induced by viruses. In this review, we focus on the beneficial and detrimental role of TLR9 in gynecological carcinogenesis. TLR9 contributes to tumor regression by inducing cytotoxic T cell response (CTL), reducing the numbers of myeloid-derived suppressor cells (MDSCs), the tumor-associated macrophages (TAMs) and the regulatory T cells (T regs). It can however, also promote tumor progression and invasiveness of cervical tissue. Therefore, the dichotomous role of TLR9 needs to be carefully investigated in the setting of neoplastic disease.
Assuntos
Neoplasias dos Genitais Femininos/imunologia , Proteínas de Neoplasias/fisiologia , Receptor Toll-Like 9/fisiologia , Carcinogênese , Progressão da Doença , Feminino , Neoplasias dos Genitais Femininos/patologia , Neoplasias dos Genitais Femininos/virologia , Interações Hospedeiro-Patógeno , Humanos , Imunidade Inata , Inflamação , Macrófagos/imunologia , Células Supressoras Mieloides/imunologia , NF-kappa B/metabolismo , Invasividade Neoplásica , Neovascularização Patológica/fisiopatologia , Papillomaviridae/patogenicidade , Infecções por Papillomavirus/imunologia , Linfócitos T Reguladores/imunologia , Receptor Toll-Like 9/agonistasRESUMO
OBJECTIVE: The aim of this study was to investigate mucosal expression of INF-gamma and IL-10 in patients with Crohn's disease (CD) or ulcerative colitis (UC). METHODS: Fourteen patients with CD and 11 patients with ulcerative colitis participated and 7 healthy subjects were also included. Study of the mucosal expression of INF-gamma and IL-10 was conducted using biopsies from healthy and damaged colons, using the inverse transcription and genetic amplification (RT-PCR) technique in real time (Taqman). Our results were expressed as ratio between messenger cytokine (mRNA) levels and ribosomal RNA level of a reference molecule (rRNA 18S), then multiplied by 108. RESULTS: In the cases of Crohn's disease, the mucosa expressed increased INF-gamma and IL-10 compared with controls (respective medians: 23.03 vs. 1.87 p=0.04 and 20.61 vs. 2.13 p=0.08). A strong positive correlation was found in the mucosal expression of IL-10 and INF-gamma during CD (r=0.9 p<0.0001). In contrast, in patients with UC, the expression of INF-gamma and IL-10 were comparable to those observed in the controls (7.18 vs. 2.18 p=0.36 and 3.66 vs. 1.87 p=0.44). CONCLUSION: During Crohn's disease, the expression of both IL-10 and INF-gamma was increased and strongly correlated, compared with the controls.
Assuntos
Colite Ulcerativa/patologia , Colo/química , Doença de Crohn/patologia , Expressão Gênica/genética , Interferon gama/genética , Interleucina-10/genética , Mucosa Intestinal/química , Adolescente , Adulto , Biópsia , Estudos de Casos e Controles , Criança , Colite Ulcerativa/imunologia , Colo/imunologia , Colonoscopia , Doença de Crohn/imunologia , Regulação para Baixo/genética , Regulação para Baixo/imunologia , Feminino , Expressão Gênica/imunologia , Perfilação da Expressão Gênica , Humanos , Imunidade nas Mucosas/genética , Imunidade nas Mucosas/imunologia , Interferon gama/análise , Interferon gama/imunologia , Interleucina-10/análise , Interleucina-10/imunologia , Mucosa Intestinal/imunologia , Masculino , Pessoa de Meia-Idade , RNA Mensageiro/genética , RNA Ribossômico , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Índice de Gravidade de Doença , Transcrição Gênica/genética , Transcrição Gênica/imunologiaRESUMO
As apoptosis and necrosis are known to exist during experimental goiter development and involution, we studied them in ten Tunisian multinodular endemic goiters, five of them having received a chronic excess of iodine during six months. Apoptotic thyrocyte nuclei have been counted on hematoxylin-eosin stained semi-thin sections. Using immunoperoxidase on paraffin sections, bcl-2 and bax immunoreactivities have been evidenced, and CD34 positive microvessels counted; ultra-thin sections have also been observed. After six months of iodine overload, apoptotic thyrocytes were ten times more numerous; CD34 positive endothelial cells were diminished by one half bcl-2 immunoreactivity disappeared in thyrocytes and a bax one appeared in thyroid follicular and endothelial cells. Presence of numerous apoptotic follicular and endothelial cells was confirmed using electron microscopy. Chronic iodine excess induces apoptosis and necrosis of thyroid follicular and endothelial cells, leading to thyroglobulin accumulation in connective tissue.
Assuntos
Apoptose/efeitos dos fármacos , Bócio Endêmico/tratamento farmacológico , Bócio Endêmico/patologia , Iodetos/intoxicação , Antígenos CD34/análise , Capilares/química , Capilares/efeitos dos fármacos , Doença Crônica , Deficiências Nutricionais/complicações , Deficiências Nutricionais/epidemiologia , Deficiências Nutricionais/prevenção & controle , Esquema de Medicação , Genes bcl-2 , Bócio Endêmico/epidemiologia , Bócio Endêmico/etiologia , Bócio Endêmico/cirurgia , Humanos , Técnicas Imunoenzimáticas , Iodetos/administração & dosagem , Iodo/deficiência , Necrose , Cuidados Pré-Operatórios , Tireoglobulina/análise , Tunísia/epidemiologia , Proteína X Associada a bcl-2/análiseRESUMO
Hereditary epidermolysis bullosa (EB) are a group of genodermatoses whose common primary feature is formation of blisters following minor trauma. The aim of the present study was to assess epidemiological, clinical, genetical and histological particularities of patients with hereditary epidermolysis bullosa.
Assuntos
Epidermólise Bolhosa , Adolescente , Adulto , Distribuição por Idade , Biópsia , Criança , Pré-Escolar , Consanguinidade , Epidermólise Bolhosa/classificação , Epidermólise Bolhosa/epidemiologia , Epidermólise Bolhosa/genética , Epidermólise Bolhosa/patologia , Genes Dominantes/genética , Genes Recessivos/genética , Humanos , Lactente , Recém-Nascido , Microscopia Eletrônica de Transmissão e Varredura , Pessoa de Meia-Idade , Linhagem , Vigilância da População , Prevalência , Doenças Raras , Estudos Retrospectivos , Índice de Gravidade de Doença , Tunísia/epidemiologiaRESUMO
The subcellular localization of cerium and lanthanum in the intestinal mucosa was studied after oral administration of cerium chloride or lanthanum chloride or lanthanum chloride followed 30 minutes after of cerium chloride to young adults Wistar rats. Two methods of observation and microanalysis were used. The transmission electron microscopy revealed the presence of dense electron granulations in the lysosmes of the duodenum enterocyte, when these elements were administrated simultaneously. The ion mass microanalysis permits to detect the presence of La and Ce as bright points outlining the intestinal villi. These points correspond to the lysosomes containing the granulations previously described. These granulations are formed by the cerium and the lanthanum associated to the phosphor and forming probably insoluble salts of Ce/La phosphate.
Assuntos
Cério/administração & dosagem , Duodeno/efeitos dos fármacos , Mucosa Intestinal/efeitos dos fármacos , Lantânio/administração & dosagem , Administração Oral , Animais , Cério/análise , Cério/farmacocinética , Avaliação Pré-Clínica de Medicamentos , Duodeno/química , Duodeno/ultraestrutura , Microanálise por Sonda Eletrônica , Enterócitos/química , Enterócitos/efeitos dos fármacos , Enterócitos/ultraestrutura , Tecido de Granulação/química , Tecido de Granulação/efeitos dos fármacos , Tecido de Granulação/ultraestrutura , Absorção Intestinal , Mucosa Intestinal/química , Mucosa Intestinal/ultraestrutura , Lantânio/análise , Lantânio/farmacocinética , Lisossomos/química , Lisossomos/efeitos dos fármacos , Lisossomos/ultraestrutura , Microscopia Eletrônica de Transmissão e Varredura , Ratos , Ratos Wistar , Soluções , Fatores de TempoRESUMO
The authors report a case of Scrotal subcutaneous dirofilariasis in man for the first time in Tunisia. The diagnosis was established by pathological examination of a biopsy but the identification of the species was not possible. Surgical exeresis of the node was followed by a complete recovery.
Assuntos
Dirofilariose/diagnóstico , Dermatopatias Parasitárias/diagnóstico , Adulto , Biópsia , Dirofilariose/cirurgia , Humanos , Masculino , Escroto , Pele/parasitologia , Dermatopatias Parasitárias/cirurgia , TunísiaRESUMO
Tracheobronchopathia osteochondroplastica (TBOC) is an unusual respiratory disorder characterized by cartilaginous or bony mucosal nodules in the tracheobronchial tree. It mainly affects men over 50 years old and clinical manifestations are observed when obstructive or infectious complications occur. We report a case of tracheopathia osteoplastica of the upper third of the trachea in a young 35-year-old mal, fortuitously discovered while exploring a biliptysis caused by a broken hydatic cyst of the liver. TBOC can be associated with various metabolic, inflammatory and neoplastic disorders, but its pathogenesis remains unknown. A metaplastic origin is actually the main hypothesis proposed.
Assuntos
Brônquios/patologia , Equinococose Hepática/diagnóstico , Osteocondrodisplasias/diagnóstico , Doenças da Traqueia/diagnóstico , Adulto , Equinococose Hepática/complicações , Equinococose Hepática/patologia , Humanos , Masculino , Osteocondrodisplasias/complicações , Osteocondrodisplasias/patologia , Doenças da Traqueia/complicações , Doenças da Traqueia/patologiaRESUMO
We report a case of minimal deviation adenocarcinoma of the uterine cervix in a 32 year old women who present a Peutz Jeghers syndrome. This patient also had fibroadenoma of the breast and dystrophic mastopathy. This case represent an example of predisposition to developing tumors of the Peutz Jeghers syndrome.
Assuntos
Adenocarcinoma/complicações , Síndrome de Peutz-Jeghers/complicações , Neoplasias do Colo do Útero/complicações , Adenocarcinoma/patologia , Adulto , Diferenciação Celular/fisiologia , Feminino , Humanos , Síndrome de Peutz-Jeghers/patologia , Neoplasias do Colo do Útero/patologiaRESUMO
Two cases of aggressive angiomyxoma of the pelvis and perineum are described; the first occurred in 32 year old woman who had a vulvar mass, the second in a 78 year old man who presented inguinal hernia. This recently described entity is characterized by its microscopic appearance (low cellularity, loose myxoid stroma and prominent vascular component), and propensity to local aggressivity, and common recurrence after surgery.
Assuntos
Mixoma/patologia , Neoplasias Pélvicas/patologia , Períneo , Testículo , Adulto , Idoso , Feminino , Hérnia Inguinal/complicações , Humanos , Masculino , Invasividade Neoplásica , Neoplasias Vulvares/patologiaRESUMO
The authors report one exceptional case of organic small bowel occlusion. The etiological diagnosis was performed by ultrasonographic examination and showed two hydatid cysts of the liver opened into the peritoneum and a peritoneal fluid collection corresponding to the hydatid fluid. The authors emphasize the absence of clinical symptoms during the opening of the hydatid cysts of the liver into the peritoneum and the usefulness of emergency ultrasonographic examination of the entire abdomen in cases of small bowel obstruction without any evident etiology.