Detalhe da pesquisa
1.
Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B KATP Channels.
Mol Pharmacol
; 105(3): 202-212, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38302135
2.
Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification.
Gastroenterology
; 165(3): 656-669.e8, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37271289
3.
Persistent challenges in the development of an mGlu7 PAM in vivo tool compound: The discovery of VU6046980.
Bioorg Med Chem Lett
; 80: 129106, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36528230
4.
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
Bioorg Med Chem Lett
; 87: 129256, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36966977
5.
VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels.
Mol Pharmacol
; 101(5): 357-370, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35246480
6.
Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis.
Gastroenterology
; 160(4): 1256-1268.e9, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33189701
7.
Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1.
Bioorg Med Chem Lett
; 47: 128193, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34118412
8.
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs.
Bioorg Med Chem Lett
; 32: 127724, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33253881
9.
Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model.
Bioorg Med Chem Lett
; 37: 127838, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33556572
10.
Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.
FASEB J
; 33(1): 1033-1041, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30096040
11.
Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension.
Am J Physiol Heart Circ Physiol
; 316(3): H639-H646, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30608177
12.
Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.
Brain
; 139(Pt 7): 2063-81, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27190010
13.
Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.
J Neurosci
; 34(17): 5882-94, 2014 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24760848
14.
Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells.
J Mol Cell Cardiol
; 79: 295-302, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25463275
15.
Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers.
J Lipid Res
; 56(11): 2196-205, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26378094
16.
Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA.
Biochemistry
; 53(15): 2436-41, 2014 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24684440
17.
Protein modification by adenine propenal.
Chem Res Toxicol
; 27(10): 1732-42, 2014 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25211669
18.
Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists.
ACS Med Chem Lett
; 15(2): 302-309, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38352850
19.
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.
Proc Natl Acad Sci U S A
; 107(6): 2699-704, 2010 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20133658
20.
Protein adduction causes non-mutational inhibition of p53 tumor suppressor.
Cell Rep
; 42(1): 112024, 2023 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36848235