Detalhe da pesquisa
1.
Survey of pharmaceutical industry's best practices around in vitro transporter assessment and Implications for Drug Development: Considerations from the IQ Transporter Working Group.
Drug Metab Dispos
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38697852
2.
Quantitation of Plasma Membrane Drug Transporters in Kidney Tissue and Cell Lines Using a Novel Proteomic Approach Enabled a Prospective Prediction of Metformin Disposition.
Drug Metab Dispos
; 49(10): 938-946, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34330717
3.
Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 30(7): 126986, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32046903
4.
Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.
Bioorg Med Chem
; 28(1): 115208, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31740203
5.
Translation of In Vitro Transport Inhibition Studies to Clinical Drug-Drug Interactions for Glecaprevir and Pibrentasvir.
J Pharmacol Exp Ther
; 370(2): 278-287, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167814
6.
Mechanisms and Predictions of Drug-Drug Interactions of the Hepatitis C Virus Three Direct-Acting Antiviral Regimen: Paritaprevir/Ritonavir, Ombitasvir, and Dasabuvir.
Drug Metab Dispos
; 45(7): 755-764, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28483778
7.
Validation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions.
Xenobiotica
; 47(9): 825-832, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27609543
8.
In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia.
Xenobiotica
; 44(3): 276-82, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23886114
9.
Coproporphyrin I Can Serve as an Endogenous Biomarker for OATP1B1 Inhibition: Assessment Using a Glecaprevir/Pibrentasvir Clinical Study.
Clin Transl Sci
; 14(1): 373-381, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33048456
10.
Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530).
J Med Chem
; 63(19): 11034-11044, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32881503
11.
No Inhibition of MATE1/2K-Mediated Renal Creatinine Secretion Predicted With Ritonavir or Cobicistat.
J Pharm Sci
; 108(9): 3118-3123, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31034908
12.
Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes.
Drug Metab Dispos
; 36(1): 198-202, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17954525
13.
Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound-The Venetoclax Story.
J Pharm Sci
; 107(1): 495-502, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28993217
14.
Prediction of clinical drug-drug interactions of veliparib (ABT-888) with human renal transporters (OAT1, OAT3, OCT2, MATE1, and MATE2K).
J Pharm Sci
; 102(12): 4426-32, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24122511
15.
The impact of plasma protein binding on the renal transport of organic anions.
J Pharmacol Exp Ther
; 316(1): 349-55, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16195420
16.
Molecular aspects of the transport and toxicity of ochratoxin a.
Acc Chem Res
; 37(11): 874-81, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15612677