RESUMO
BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the most widespread cancer types that arise from different sites of oral cavity and has a 5-year survival rate. This study is aimed at investigating the human oxoguanine glycosylase 1 (hOGG1)-Ser326Cys and APE-Asp148Glu polymorphisms of DNA repair genes in OSCC. MATERIALS AND METHODS: We investigated the hOGG1-Ser326Cys and APE-Asp148Glu polymorphisms of DNA repair genes in the oral cavity. Genotyping was conducted using polymerase chain reaction-restriction fragment length polymorphism analysis based on 132 patients who were diagnosed as having OSCC and 160 healthy subjects. RESULTS: Individuals with the genotype hOGG1-Ser326Cys, Cys allele carriers, were found significantly more frequently in the patient group compared to the control group as increase in risk (p < 0.001). Furthermore, it was observed that there were significantly more individuals with the Ser allele in the control group (p < 0.001). Individuals with genotype APE-Asp148Glu were not statistically significant; however, they were still more in the control group and provided protection against the disease. CONCLUSION: Our findings showed that hOGG1-Ser326Cys Cys allele is statistically important and relevant with respect to the development of oral squamous cancer. In view of our results, further studies including expression levels are required in which hOGG1-Ser326Cys should be investigated as molecular biomarkers for the early prediction of squamous cell carcinoma.
Assuntos
Carcinoma de Células Escamosas/genética , DNA Glicosilases/genética , Variação Genética , Neoplasias Bucais/genética , Adulto , Idoso , Alelos , Carcinoma de Células Escamosas/enzimologia , Carcinoma de Células Escamosas/patologia , Feminino , Genótipo , Humanos , Masculino , Neoplasias Bucais/enzimologia , Neoplasias Bucais/patologia , Polimorfismo de Fragmento de Restrição , RiscoRESUMO
Burning mouth syndrome (BMS) is characterized by oral burning or similar pain in the absence of detectable oral mucosa changes. This condition is more common among middle-aged and elderly women. Although various local, systemic, and psychological factors are considered to be possible causes of BMS, it is still a challenge in the field of oral medicine. The aim of this review was to discuss several aspects of BMS, update current knowledge, and provide guidelines for patient management.
Assuntos
Síndrome da Ardência Bucal/etiologia , Síndrome da Ardência Bucal/terapia , Síndrome da Ardência Bucal/diagnóstico , Síndrome da Ardência Bucal/epidemiologia , Humanos , Estado Nutricional , Higiene Bucal , Prevalência , Fatores de RiscoRESUMO
PURPOSE: Studies regarding oral health are mainly conducted on adult population and there is a lack of epidemiologic data on the oral health of children. The purpose of this study was to evaluate the prevalence and distribution of oral lesions in Turkish children. MATERIALS AND METHODS: A cross-sectional survey was carried out on total of 1041 Turkish children attended by the outpatient Oral Medicine and Surgery Department of Istanbul University. RESULTS: Examinations were performed and 277 of whom had a total of more than 30 different type of lesions detected. The fissured tongue (3.4%) was the most frequent lesion, followed by traumatic lesions (3.2%) and the cheek biting (2.5%). CONCLUSION: This is the first study in Turkey on oral lesions in this age group. We hope that our study will be a baseline data for future studies and for sure there is a need for more goodquality epidemiological studies in this area.