Detalhe da pesquisa
1.
Phase 1 study of safety and tolerability of an oral contraceptive containing low-dose ethinyl oestradiol combined with glecaprevir/pibrentasvir treatment in healthy premenopausal women.
J Viral Hepat
; 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38654438
2.
Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.
Bioorg Med Chem Lett
; 20(5): 1551-4, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149650
3.
The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.
Bioorg Med Chem Lett
; 19(16): 4563-5, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19625185
4.
Recent advances in the discovery of 11beta-HSD1 inhibitors.
Curr Opin Drug Discov Devel
; 11(4): 495-511, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18600567
5.
Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists.
Bioorg Med Chem Lett
; 18(14): 4199-203, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18562199
6.
Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists.
Bioorg Med Chem Lett
; 18(14): 4204-9, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18558486
7.
Discovery of MK-8282 as a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes.
ACS Med Chem Lett
; 9(5): 457-461, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795759
8.
Structure-activity relationship studies: M2 and CCR5 receptor antagonists.
Curr Top Med Chem
; 3(10): 1155-69, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12769714
9.
Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists.
J Med Chem
; 45(25): 5415-8, 2002 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12459007
10.
11beta-hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents.
Expert Opin Ther Pat
; 19(6): 801-25, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19456274
11.
T-wave abnormalities are a better predictor of cardiovascular mortality than ST depression on the resting electrocardiogram.
Ann Noninvasive Electrocardiol
; 10(2): 146-51, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15842426
12.
Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.
Bioorg Med Chem Lett
; 15(9): 2365-9, 2005 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15837326
13.
Synthesis of mono- and difluoronaphthoic acids.
J Org Chem
; 67(4): 1171-7, 2002 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11846659
14.
SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.
Bioorg Med Chem Lett
; 14(5): 1291-4, 2004 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-14980684
15.
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.
Bioorg Med Chem Lett
; 12(23): 3479-82, 2002 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-12419388
16.
Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors.
Bioorg Med Chem Lett
; 12(21): 3149-52, 2002 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12372521