RESUMO
BACKGROUND: Approximately 10% of IDH-mutant gliomas harbour non-canonical IDH mutations (non-p.R132H IDH1 and IDH2 mutations). OBJECTIVE: The aim of this study was to analyse the characteristics of non-canonical IDH-mutant gliomas. MATERIALS AND METHODS: We retrospectively analysed the characteristics of 166 patients with non-canonical IDH mutant gliomas and compared them to those of 155 consecutive patients with IDH1 p.R132H mutant gliomas. RESULTS: The median age at diagnosis was 38 years in patients with non-canonical IDH mutant gliomas and 43 years in glioma patients with IDH1 p.R132H-mutant tumours. Family history of cancer was more frequent among glioma patients harbouring non-canonical IDH mutations than in patients with IDH1 p.R132H mutations (22.2% vs 5.1%; P < 0.05). Tumours were predominantly localised in the frontal lobe regardless of the type of IDH mutation. Compared to IDH1 p.R132H-mutant gliomas, tumours with non-canonical IDH mutations were more frequently found in the infratentorial region (5.5% vs 0%; P < 0.05) and were often multicentric (4.8% vs 0.9%; P < 0.05). Compared to IDH1 P.R132H-mutant gliomas, tumours with non-canonical IDH1 mutations were more frequently astrocytomas (65.6% vs 43%, P < 0.05), while those with IDH2 mutations were more frequently oligodendrogliomas (85% vs 48.3%; P < 0.05). The median overall survival was similar in patients with IDH1 p.R132H-mutant gliomas and patients with non-canonical IDH-mutant gliomas. CONCLUSION: Gliomas with non-canonical IDH mutations have distinct radiological and histological characteristics. The presence of such tumours seems to be associated with genetic predisposition to cancer development.
Assuntos
Neoplasias Encefálicas/patologia , Glioma/patologia , Isocitrato Desidrogenase/genética , Mutação , Adulto , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/terapia , Terapia Combinada , Feminino , Seguimentos , Predisposição Genética para Doença , Glioma/genética , Glioma/terapia , Humanos , Masculino , Prognóstico , Taxa de SobrevidaAssuntos
Anilidas/efeitos adversos , Antineoplásicos/efeitos adversos , Piridinas/efeitos adversos , Acidente Vascular Cerebral/induzido quimicamente , Acidente Vascular Cerebral/diagnóstico , Doenças Assintomáticas , Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/secundário , Carcinoma de Células Renais/tratamento farmacológico , Humanos , Neoplasias Renais/tratamento farmacológico , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/patologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , NeuroimagemRESUMO
We report on the application of the PILATUS 100K pixel detector for medical imaging. Experimental results are presented in the form of X-ray radiographs using standard X-ray absorption contrast and a recently developed phase contrast imaging method. The results obtained with the PILATUS detector are compared to results obtained with a conventional X-ray imaging system consisting of an X-ray scintillation screen, lens optics, and a charge coupled device. Finally, the results for both systems are discussed more quantitatively based on an image power spectrum analysis.
Assuntos
Interpretação de Imagem Radiográfica Assistida por Computador/métodos , Radiografia/métodos , Animais , Galinhas , Humanos , Interpretação de Imagem Radiográfica Assistida por Computador/instrumentação , Radiografia/instrumentação , Asas de Animais/diagnóstico por imagemRESUMO
The target field method of designing gradient coils is extended to the case where the gradient producing currents lie on cylinders of a general orientation with respect to the polarizing magnetic field. This provides a general approach for designing coils that require unusual sample geometries such as those required for magic angle spinning (MAS) applications. A detailed example of a magic angle gradient coil set for MAS is given.
Assuntos
Espectroscopia de Ressonância Magnética/instrumentação , Desenho de Equipamento , MatemáticaRESUMO
Synchrotron beam measurements were performed with a single-photon-counting pixel detector to investigate the influence of threshold settings on charge sharing. Improvement of image homogeneity by adjusting the threshold of each pixel individually was demonstrated. With a flat-field correction, the homogeneity could be improved. A measurement of the point spread function is reported.