Detalhe da pesquisa
1.
Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer.
Breast Cancer Res Treat
; 184(1): 53-62, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32803633
2.
A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors.
Invest New Drugs
; 32(4): 653-60, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24604265
3.
Anti-neuropilin-1 (MNRP1685A): unexpected pharmacokinetic differences across species, from preclinical models to humans.
Pharm Res
; 29(9): 2512-21, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22707361
4.
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.
Int J Cancer
; 128(2): 304-18, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20309933
5.
Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins.
Nucleic Acids Res
; 36(1): e8, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18086703
6.
Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.
Proc Natl Acad Sci U S A
; 104(47): 18613-8, 2007 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18003932
7.
Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer.
Clin Cancer Res
; 26(20): 5348-5357, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32694153
8.
Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants.
Bioinformatics
; 23(13): i104-14, 2007 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17646286
9.
Overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation.
Cancer Res
; 66(6): 3137-44, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16540664
10.
A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors.
Clin Cancer Res
; 23(24): 7490-7497, 2017 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28954784
11.
Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants.
IEEE/ACM Trans Comput Biol Bioinform
; 3(2): 114-25, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17048398
12.
Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites.
Oncogene
; 21(51): 7901-11, 2002 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12420228
13.
A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 73(5): 951-60, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24633809
14.
Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models.
Clin Cancer Res
; 18(24): 6771-83, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23136191
15.
ATP, Cancer and p53.
Cancer Biol Ther
; 3(7): 638-40, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15326374
16.
Genetic strategies in Saccharomyces cerevisiae to study human tumor suppressor genes.
Methods Mol Biol
; 223: 73-86, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12777721
17.
hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin.
Cancer Biol Ther
; 7(1): 120-8, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18059173
18.
Heterogeneous biomedical database integration using a hybrid strategy: a p53 cancer research database.
Cancer Inform
; 2: 277-87, 2007 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19458771
19.
Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers.
Carcinogenesis
; 28(2): 289-98, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16861262
20.
p53 mutants: the achilles' heel of human cancers?
Cell Cycle
; 3(8): 1030-4, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15280671