Detalhe da pesquisa
1.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
2.
Phase 3 study evaluating the safety and efficacy of oteseconazole in the treatment of recurrent vulvovaginal candidiasis and acute vulvovaginal candidiasis infections.
Am J Obstet Gynecol
; 227(6): 880.e1-880.e11, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35863457
3.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc Natl Acad Sci U S A
; 116(19): 9318-9323, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962368
4.
A Randomized Phase 2 Study of VT-1161 for the Treatment of Acute Vulvovaginal Candidiasis.
Clin Infect Dis
; 73(7): e1518-e1524, 2021 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32818963
5.
Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.
Bioorg Chem
; 115: 105244, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34452759
6.
Enantiomerically enriched, polycrystalline molecular sieves.
Proc Natl Acad Sci U S A
; 114(20): 5101-5106, 2017 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28461490
7.
In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104280
8.
The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29987152
9.
A phase 2, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal candidiasis.
Am J Obstet Gynecol
; 218(6): 624.e1-624.e9, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534874
10.
The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii.
Antimicrob Agents Chemother
; 60(4): 2528-31, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26787697
11.
Facile Synthesis, Characterization, and Catalytic Behavior of a Large-Pore Zeolite with the IWV Framework.
Chemistry
; 22(12): 4022-9, 2016 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26833857
12.
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Nature
; 464(7289): 728-32, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20360736
13.
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Eur J Med Chem
; 270: 116354, 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38554474
14.
7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex.
ACS Infect Dis
; 9(3): 668-691, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36853190
15.
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
J Med Chem
; 66(5): 3540-3565, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812492
16.
Efficacy and Safety of Oteseconazole in Recurrent Vulvovaginal Candidiasis.
NEJM Evid
; 1(8): EVIDoa2100055, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-38319878
17.
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science
; 376(6597): 1074-1079, 2022 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653481
18.
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 64(9): 5905-5930, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33904304
19.
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines.
J Med Chem
; 64(7): 4150-4162, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33759519
20.
Structural identification of recombinant human CD83 mutant variant as a potent therapeutic protein.
Protein Expr Purif
; 73(2): 140-6, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20566323