Prefrontal cortex and putamen grey matter alterations in cannabis and tobacco users.

BACKGROUND: Previous magnetic resonance imaging studies in regular cannabis users report altered grey matter volume (GMV) in brain regions, including the prefrontal cortex (PFC), putamen and hippocampus. However, most studies have tended to recruit recreational users with high levels of cannabis use, and have not controlled for the possible confounding effects of tobacco use. We attempt to address these limitations in the present study. METHODS: We acquired volumetric images in sex, age and IQ-matched groups of (1) regular Cannabis users who also smoke Tobacco cigarettes ('CT'; n = 33), (2) non-cannabis-using Tobacco cigarette smokers ('T'; n = 19) and (3) non-cannabis/tobacco-using Controls ('C'; n = 35). GMV in bilateral PFC, putamen and hippocampal regions was compared across groups. We also examined the associations between GMV differences and levels of cannabis and tobacco use, measures of intellectual function, and of depression, anxiety and stress. RESULTS: Relative to controls, both CT and T groups showed lower GMV in the left inferior frontal gyrus, and greater GMV in the putamen. In addition, lower GMV in the right frontal pole in the CT group (but not the T group) was associated with lifetime cannabis use, but not with cigarette use. CONCLUSIONS: Regular cannabis users who also smoked tobacco cigarettes showed altered GMV patterns relative to controls. However, a similar pattern of GMV differences was also seen between regular tobacco users that did not use cannabis. Further research is needed to disentangle the effects of cannabis and tobacco use on brain structure.

It takes me back: The mnemonic time-travel effect.

Given the links between motion and temporal thinking, it is surprising that no studies have examined the possibility that transporting participants back mentally towards the time of encoding could improve memory. Six experiments investigated whether backward motion would promote recall relative to forward motion or no-motion conditions. Participants saw a video of a staged crime (Experiments 1, 3 and 5), a word list (Experiments 2 and 4) or a set of pictures (Experiment 6). Then, they walked forward or backwards (Experiments 1 and 2), watched a forward- or backward-directed optic flow-inducing video (Experiments 3 and 4) or imagined walking forward or backwards (Experiments 5 and 6). Finally, they answered questions about the video or recalled words or pictures. The results demonstrated for the first time that motion-induced past-directed mental time travel improved mnemonic performance for different types of information. We briefly discuss theoretical and practical implications of this "mnemonic time-travel effect".