Detalhe da pesquisa
1.
Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders.
Bioorg Med Chem
; 23(10): 2387-407, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25882525
2.
Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.
Bioorg Med Chem
; 22(15): 4135-50, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980703
3.
Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors.
Bioorg Med Chem
; 22(17): 4998-5012, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25009002
4.
Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90).
Bioorg Med Chem
; 21(22): 7047-63, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24100158
5.
5-(2-amino-pyrimidin-4-yl)-1H-pyrrole and 2-(2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one derivatives as new classes of selective and orally available Polo-like kinase 1 inhibitors.
Bioorg Med Chem Lett
; 22(1): 96-101, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22154349
6.
NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor.
Bioorg Med Chem Lett
; 21(10): 2969-74, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21470862
7.
The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound.
Pharmacol Res
; 61(5): 437-48, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20026273
8.
4,5-Dihydro-1H-pyrazolo[4,3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors.
Bioorg Med Chem Lett
; 20(22): 6489-94, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20932759
9.
Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing.
Bioorg Med Chem
; 18(5): 1844-53, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20153204
10.
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization.
J Med Chem
; 48(8): 2944-56, 2005 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15828833
11.
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding.
J Med Chem
; 47(13): 3367-80, 2004 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15189033
12.
Identification of potent pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinase inhibitors.
J Med Chem
; 53(5): 2171-87, 2010 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20141146
13.
Dual targeting of CDK and tropomyosin receptor kinase families by the oral inhibitor PHA-848125, an agent with broad-spectrum antitumor efficacy.
Mol Cancer Ther
; 9(8): 2243-54, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20682657
14.
Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors.
J Med Chem
; 53(9): 3532-51, 2010 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20397705
15.
Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor.
J Med Chem
; 52(16): 5152-63, 2009 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19603809
16.
Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.
J Med Chem
; 52(14): 4380-90, 2009 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19555113
17.
Polyfluorinated amino acids for sensitive 19F NMR-based screening and kinetic measurements.
J Am Chem Soc
; 129(17): 5665-72, 2007 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17417847
18.
6-Substituted pyrrolo[3,4-c]pyrazoles: an improved class of CDK2 inhibitors.
ChemMedChem
; 2(6): 841-52, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17450625
19.
A practical synthesis of the major 3-hydroxy-2-pyrrolidinone metabolite of a potent CDK2/cyclin A inhibitor.
Bioorg Med Chem Lett
; 16(12): 3205-8, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16616492
20.
3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.
Bioorg Med Chem Lett
; 16(4): 1084-90, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16290148