Detalhe da pesquisa
1.
Common bile duct polyp: an infrequent cause of jaundice and biliary obstruction.
Endoscopy
; 56(S 01): E242-E243, 2024 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38458245
2.
Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 24(3): 954-62, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24433859
3.
Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
Bioorg Med Chem Lett
; 24(18): 4546-4552, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25139565
4.
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Science
; 383(6682): eadi5798, 2024 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38301010
5.
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.
Nat Chem Biol
; 7(1): 41-50, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21113169
6.
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
J Med Chem
; 60(2): 627-640, 2017 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28005357
7.
Tailoring small molecules for an allosteric site on procaspase-6.
ChemMedChem
; 9(1): 73-7, 2, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24259468
8.
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.
Cancer Cell
; 26(3): 402-413, 2014 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25155755
9.
Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization.
J Med Chem
; 57(8): 3484-93, 2014 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24673130
10.
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
J Med Chem
; 57(3): 770-92, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24405419
11.
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
PLoS One
; 7(12): e50864, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23227217
12.
Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449).
J Med Chem
; 54(8): 2592-601, 2011 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21438527