Detalhe da pesquisa
1.
Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold.
Proc Natl Acad Sci U S A
; 120(37): e2305494120, 2023 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37669364
2.
Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.
Proc Natl Acad Sci U S A
; 113(49): E7880-E7889, 2016 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27864515
3.
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
J Med Chem
; 66(4): 2918-2945, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36727211
4.
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.
J Med Chem
; 66(13): 9147-9160, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37395055
5.
Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.
Bioorg Med Chem Lett
; 22(4): 1510-9, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22297115
6.
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.
Bioorg Med Chem Lett
; 22(6): 2330-7, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22342147
7.
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.
J Med Chem
; 65(9): 6940-6952, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35471939
8.
Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.
Bioorg Med Chem Lett
; 20(17): 5133-8, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20673630
9.
Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.
J Med Chem
; 63(23): 14530-14559, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32910656
10.
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C.
J Med Chem
; 63(9): 4468-4483, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32023060
11.
Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.
ACS Med Chem Lett
; 10(10): 1492-1497, 2019 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31620239
12.
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun
; 10(1): 2607, 2019 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31197133
13.
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).
J Med Chem
; 62(24): 11004-11018, 2019 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31710489
14.
Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.
Bioorg Med Chem Lett
; 18(20): 5487-92, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18815031
15.
Computational Design of Epitope-Specific Functional Antibodies.
Cell Rep
; 25(8): 2121-2131.e5, 2018 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30463010
16.
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
J Med Chem
; 61(3): 1061-1073, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29301085
17.
Molecular determinants for substrate specificity of the ligand-binding protein OpuAC from Bacillus subtilis for the compatible solutes glycine betaine and proline betaine.
J Mol Biol
; 357(2): 592-606, 2006 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16445940
18.
Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Nat Commun
; 8: 16111, 2017 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28706291
19.
N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
J Med Chem
; 49(22): 6465-88, 2006 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064066
20.
Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion.
Structure
; 11(10): 1291-301, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14527396