Detalhe da pesquisa
1.
AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington's disease mouse model.
Brain
; 146(6): 2298-2315, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36508327
2.
Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents.
Bioorg Med Chem Lett
; 72: 128858, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35718104
3.
SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease.
Bioorg Med Chem
; 57: 116631, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35123179
4.
Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.
Bioorg Med Chem Lett
; 30(8): 127052, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32113841
5.
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Bioorg Med Chem
; 28(21): 115738, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33065433
6.
Aspergillus olivimuriae sp. nov., a halotolerant species isolated from olive brine.
Int J Syst Evol Microbiol
; 69(9): 2899-2906, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31274407
7.
Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and ß-globin gene promoters.
Anal Bioanal Chem
; 411(29): 7669-7680, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31273412
8.
Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome.
Hum Mol Genet
; 25(20): 4369-4375, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28173146
9.
Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins.
Bioorg Med Chem Lett
; 28(9): 1540-1544, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29615344
10.
Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro.
Bioorg Med Chem Lett
; 28(23-24): 3689-3692, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30482621
11.
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
Arch Biochem Biophys
; 631: 31-41, 2017 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28801166
12.
Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome.
Hum Mol Genet
; 26(22): 4540, 2017 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29036321
13.
Salivary Huntingtin protein is uniquely associated with clinical features of Huntington's disease.
Sci Rep
; 13(1): 1034, 2023 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36658243
14.
Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases.
Life Sci
; 322: 121323, 2023 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36574942
15.
A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation.
Virology
; 583: 1-13, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37060797
16.
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.
J Med Chem
; 66(18): 13205-13246, 2023 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712656
17.
Quantifying Huntingtin Protein in Human Cerebrospinal Fluid Using a Novel Polyglutamine Length-Independent Assay.
J Huntingtons Dis
; 11(3): 291-305, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35938256
18.
Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes.
Commun Biol
; 5(1): 547, 2022 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35668202
19.
N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
Bioorg Med Chem Lett
; 21(18): 5283-8, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21802943
20.
Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
Bioorg Med Chem Lett
; 21(18): 5274-82, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21803580