RESUMO
Kielmeyera rugosa is a medicinal plant known in Northeastern Brazil as 'pau-santo', and it is used in the treatment of several tropical diseases such as malaria, schistosomiasis, and leishmaniasis. We evaluated antihyperalgesic and anti-inflammatory activities of methanol stem extract of K. rugosa (MEKR) in mice. The mechanical hyperalgesia induced by carrageenan and tumor necrosis factor-alpha (TNF-α), prostaglandin E2 , and dopamine were assessed. We also investigated the anti-inflammatory effect of MEKR on carrageenan-induced pleurisy and paw edema. Ninety minutes after the treatment, the animals were submitted to an imunofluorescence for Fos protein. MEKR (100, 200, and 400 mg/kg; p.o.) inhibited the development of mechanical hypernociception and edema. MEKR significantly decreased TNF-α and interleukin 1ß levels in pleural lavage and suppressed the recruitment of leukocytes. MEKR (1, 10, and 100 mg/mL) did not produce cytotoxicity, determined using the methyl-thiazolyl-tetrazolium assay in vitro. The locomotor activity was not affected. MEKR activated significantly the bulb olfactory, piriform cortex, and periaqueductal gray of the central nervous system. Our results provide first time evidence to propose that MEKR attenuates mechanical hyperalgesia and inflammation, in part, through an activation of central nervous system areas, mainly the periaqueductal gray and piriform cortex areas.
Assuntos
Analgésicos/farmacologia , Anti-Inflamatórios/farmacologia , Sistema Nervoso Central/efeitos dos fármacos , Citocinas/metabolismo , Hiperalgesia/tratamento farmacológico , Inflamação/tratamento farmacológico , Extratos Vegetais/farmacologia , Animais , Carragenina/efeitos adversos , Dinoprostona/metabolismo , Dopamina/metabolismo , Edema/tratamento farmacológico , Interleucina-1beta/metabolismo , Magnoliopsida/química , Masculino , Camundongos , Substância Cinzenta Periaquedutal/efeitos dos fármacos , Córtex Piriforme/efeitos dos fármacos , Caules de Planta/química , Pleurisia/tratamento farmacológico , Proteínas Proto-Oncogênicas c-fos/metabolismo , Fator de Necrose Tumoral alfa/metabolismoRESUMO
Two dichromenoxanthones [1,6-dihydroxy-6',6'-dimethylpyrano(2',3':3,4)-6'',6''-dimethylpyrano(2'',3'':7,8)xanthone (brasilixanthone A) and 1,6-dihydroxy-6',6'-dimethylpyrano(2',3':2,3)-6'',6''-dimethylpyrano(2'',3'':7,8)xanthone (brasilixanthone B)], along with betulinic acid, friedelin, sitosterol and stigmasterol were isolated from the roots and stems of Tovomita brasiliensis. Their structures were characterized on the basis of 1H and 13C NMR spectral data, including 2D NMR experiments.
Assuntos
Magnoliopsida/química , Piranos/isolamento & purificação , Xantenos/isolamento & purificação , Xantonas , Estrutura Molecular , Piranos/química , Análise Espectral , Xantenos/químicaRESUMO
Considerando que a Aromaterapia vem ao longo do tempo se consolidando como prática de grande relevância no tratamento de infecções e outras doenças do homem, decidiu-se produzir um levantamento exploratório bibliográfico desde sua origem até os dias atuais, com o intuito de acentuar cada vez mais a curiosidade e o conhecimento sobre essa arte e ciência milenar, que se apoia no uso racional dos óleos essenciais.
Over time, Aromatherapy has consolidated itself as a traditional and important practice for the treatment of infections and diseases of men. The purpose of the study is to conduct an exploratory literature review that encompasses its origin and its present-day scenario. Our intention is to call attention to the curiosity and knowledge that exists about this ancient art and science, which is based on the rational use of essential oils.