Detalhe da pesquisa
1.
Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.
Cell
; 160(3): 489-502, 2015 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25619690
2.
Degraders: The Ultimate Weapon Against Amplified Driver Kinases in Cancer.
Mol Pharmacol
; 101(4): 191-200, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35115411
3.
The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells.
J Biol Chem
; 295(25): 8470-8479, 2020 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32358059
4.
Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.
Proc Natl Acad Sci U S A
; 115(24): E5497-E5505, 2018 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29844158
5.
New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases.
Int J Mol Sci
; 22(6)2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33799513
6.
Orange is the new black: Kinases are the new master regulators of tumor suppression.
IUBMB Life
; 71(6): 738-748, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30548122
7.
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.
Mol Cell
; 35(4): 442-53, 2009 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19716789
8.
Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.
Proc Natl Acad Sci U S A
; 111(38): E3957-65, 2014 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25201979
9.
Transcriptional Repressor DAXX Promotes Prostate Cancer Tumorigenicity via Suppression of Autophagy.
J Biol Chem
; 290(25): 15406-15420, 2015 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25903140
10.
Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer.
Proc Natl Acad Sci U S A
; 110(30): 12426-31, 2013 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23836671
11.
Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation.
Arthritis Rheum
; 65(8): 2161-71, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23666743
12.
PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer.
Cell Chem Biol
; 31(2): 326-337.e11, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38016478
13.
TNIK inhibition sensitizes TNIK-overexpressing lung squamous cell carcinoma to radiotherapy.
Mol Cancer Ther
; 2024 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38670554
14.
Serine-linked PARP1 auto-modification controls PARP inhibitor response.
Nat Commun
; 12(1): 4055, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34210965
15.
TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin.
Cancer Discov
; 11(6): 1411-1423, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33495197
16.
PHLiPPing the switch on Akt and protein kinase C signaling.
Trends Endocrinol Metab
; 19(6): 223-30, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18511290
17.
Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets.
Cancers (Basel)
; 11(12)2019 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31817861
18.
Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells.
Oncogene
; 38(15): 2860-2875, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30552384
19.
Shipping Out MEK Inhibitor Resistance with SHP2 Inhibitors.
Cancer Discov
; 8(10): 1210-1212, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30279193
20.
Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases.
Sci Signal
; 11(526)2018 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29666306