Detalhe da pesquisa
1.
Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases.
Proc Natl Acad Sci U S A
; 105(15): 5728-32, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18391193
2.
Development of potential anticancer agents that target the telomere sequence.
Bioorg Med Chem Lett
; 20(13): 3982-6, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20605447
3.
Incorporation of positively charged linkages into DNA and RNA backbones: a novel strategy for antigene and antisense agents.
Chem Rev
; 112(3): 1284-309, 2012 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22074477
4.
Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8.
Biochemistry
; 47(25): 6671-7, 2008 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18512960
5.
Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents.
Bioorg Med Chem Lett
; 18(7): 2377-84, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18353646
6.
Binding properties of positively charged deoxynucleic guanidine (DNG), AgTgAgTgAgT and DNG/DNA chimeras to DNA.
Bioorg Med Chem Lett
; 18(12): 3488-91, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18514514
7.
Complexation of single strand telomere and telomerase RNA template polyanions by deoxyribonucleic guanidine (DNG) polycations: plausible anticancer agents.
Bioorg Med Chem Lett
; 18(2): 665-9, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18063368
8.
Low-frequency normal modes in horse liver alcohol dehydrogenase and motions of residues involved in the enzymatic reaction.
Biophys Chem
; 126(1-3): 80-5, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16737770
9.
An investigation of the ionic and solvation patterns of dsDNG versus dsDNA by use of molecular dynamics simulations.
Biophys Chem
; 126(1-3): 132-9, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16527389
10.
Inhibiting transcription factor/DNA complexes using fluorescent microgonotropens (FMGTs).
Biochim Biophys Acta
; 1574(1): 100-8, 2002 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-11955618
11.
Sequence specific DNA binding of Ets-1 transcription factor: molecular dynamics study on the Ets domain--DNA complexes.
J Mol Biol
; 331(2): 345-59, 2003 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12888343
12.
Determination of enzyme mechanisms by molecular dynamics: studies on quinoproteins, methanol dehydrogenase, and soluble glucose dehydrogenase.
Protein Sci
; 13(8): 1965-78, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15273299
13.
Envisioning the loop movements and rotation of the two subdomains of dihydrofolate reductase by elastic normal mode analysis.
J Biomol Struct Dyn
; 27(3): 245-58, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19795909
14.
Mechanism of product specificity of AdoMet methylation catalyzed by lysine methyltransferases: transcriptional factor p53 methylation by histone lysine methyltransferase SET7/9.
Biochemistry
; 47(9): 2743-8, 2008 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18260647
15.
A quantum mechanics/molecular mechanics study of the catalytic mechanism and product specificity of viral histone lysine methyltransferase.
Biochemistry
; 46(34): 9743-51, 2007 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17676763
16.
Temperature-dependent structure of the E x S complex of Bacillus stearothermophilus alcohol dehydrogenase.
Biochemistry
; 46(3): 837-43, 2007 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17223705
17.
Diels-Alder ribozyme catalysis: a computational approach.
J Am Chem Soc
; 129(4): 1001-7, 2007 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-17243837
18.
Catalytic mechanism and product specificity of rubisco large subunit methyltransferase: QM/MM and MD investigations.
Biochemistry
; 46(18): 5505-14, 2007 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17429949
19.
Histone lysine methyltransferase SET7/9: formation of a water channel precedes each methyl transfer.
Biochemistry
; 46(51): 14838-44, 2007 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18044969
20.
Mechanism of methanol oxidation by quinoprotein methanol dehydrogenase.
Proc Natl Acad Sci U S A
; 104(3): 745-9, 2007 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17215371