Detalhe da pesquisa
1.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249687
2.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
3.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
4.
Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin.
Molecules
; 22(4)2017 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28358310
5.
Chemical Composition and Antioxidant Activity of Euterpe oleracea Roots and Leaflets.
Int J Mol Sci
; 18(1)2016 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28036089
6.
Oenocarpus bacaba and Oenocarpus bataua Leaflets and Roots: A New Source of Antioxidant Compounds.
Int J Mol Sci
; 17(7)2016 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27355943
7.
Volatile composition and sensory properties of Vanilla × tahitensis bring new insights for vanilla quality control.
J Sci Food Agric
; 96(3): 848-58, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25754309
8.
Optimization of a DNA nicking assay to evaluate Oenocarpus bataua and Camellia sinensis antioxidant capacity.
Int J Mol Sci
; 15(10): 18023-39, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25302614
9.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
10.
Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
J Med Chem
; 64(13): 9444-9457, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138573
11.
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
J Med Chem
; 64(1): 719-740, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33395287
12.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573376
13.
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
J Med Chem
; 63(21): 13013-13030, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103428
14.
Antimalarial Pyrido[1,2- a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies.
ACS Infect Dis
; 5(3): 372-384, 2019 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30608648
15.
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.
J Med Chem
; 61(13): 5692-5703, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889526
16.
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
J Med Chem
; 61(20): 9371-9385, 2018 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30256636
17.
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
J Med Chem
; 61(9): 4213-4227, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29665687
18.
Phenolic Profiling for Traceability of Vanilla ×tahitensis.
Front Plant Sci
; 8: 1746, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29075276
19.
Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of ß-Hematin Formation.
ACS Infect Dis
; 3(6): 411-420, 2017 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28440625
20.
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
J Med Chem
; 60(4): 1432-1448, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094524