1.
Eur J Cell Biol
; 28(1): 151-4, 1982 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6813120
RESUMO
Tetrahymena pyriformis GL is a suitable model to study the influence on phagocytotic activity of two membrane-stabilizing benzimidazole nitrogen mustard derivative, ZIMET 3164 and ZIMET 3393 (cytostasan). Treatment by both compounds causes a gradual inhibition of food vacuole formation dependent on the concentrations used. Complete cessation of phagocytosis is observed by 5 micrograms/ml ZIMET 3164 and 50 micrograms/ml ZIMET 3393. Additionally, disturbances of ciliary movement including immobilization and changes of cell shape are induced. The cells resume food vacuole formation and ciliary movement after being rinsed with control solution. The results correspond well with those described recently in mammalian mononuclear phagocytes.
Assuntos
Benzimidazóis/farmacologia , Compostos de Mostarda Nitrogenada/farmacologia , Fagocitose/efeitos dos fármacos , Tetrahymena pyriformis/fisiologia , Animais , Cloridrato de Bendamustina , Cílios/efeitos dos fármacos , Relação Dose-Resposta a Droga , Tetrahymena pyriformis/efeitos dos fármacos , Vacúolos/efeitos dos fármacos
2.
Bull Acad Pol Sci Biol
; 25(3): 183-6, 1977 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-407985