Nurse Leader Mindfulness Pilot Impact on Perceived Stress: A Quality Improvement Project.

The recent COVID-19 pandemic exacerbated pre-existing stressful conditions in health care, further elevating the risk of negative health outcomes for nurses and particularly nurse leaders. The aim of this pilot project was to assess the efficacy of mindfulness practices in attenuating nurse leaders' perceived stress levels. There is a lack of evidence regarding the outcomes of stress reduction programs aimed at health care staff, especially for nurse leaders within the clinical setting. Mindfulness has been shown to have a significant positive effect on attenuating stress in a wide variety of populations. This study used a prospective longitudinal design with a volunteer nurse leader group comparing self-reported perceived stress levels before and after a brief mindfulness intervention. Results indicated a significant reduction in perceived stress among volunteer nurse leader participants postintervention. Further investigation is needed in a variety of settings to more fully understand and evaluate the potential impact of introducing mindfulness practices to support nurse leaders in hospital or clinical settings.

Combined Cardiothoracic Surgery and Liver Transplantation Versus Isolated Liver Transplantation.

OBJECTIVE: Combined cardiothoracic surgery and liver transplantation (cCSLT) recently increasingly has been used. Despite that, liver transplant immediately after cardiothoracic surgery has not been well-characterized. The authors aimed to compare perioperative management and postoperative outcomes between patients undergoing cCSLT and isolated liver transplantation (iLT). DESIGN: A retrospective study. SETTING: University tertiary medical center. PARTICIPANTS: Twenty-five cCSLT patients and 1091 iLT patients at a single institution from 2010 to 2017. INTERVENTIONS: Twenty-five cCSLT patients were compared with 100 randomly selected and 100 propensity-matched iLT patients. MEASUREMENTS AND MAIN RESULTS: All cCSLT patients underwent comprehensive preoperative evaluation by a multidisciplinary team. Of 25 cardiothoracic surgeries, heart transplant (n = 9) was most common, followed by coronary artery bypass grafting (n = 5) and lung transplant (n = 3). Intraoperative management of cCSLT was provided by 2 separate teams, one for cardiothoracic surgery and one for liver transplantation. Patients undergoing cCSLT often required cardiopulmonary bypass, an intra-aortic balloon pump, extracorporeal membrane oxygenation, or cardiac pharmacologic therapies and, additionally, needed more interventions including antifibrinolytic administration, venovenous bypass, massive blood transfusion, and platelet transfusions compared with iLT patients. Ninety-day survival rates were similar in the cCSLT (100%) and iLT groups (random iLT 87% and matched iLT 93%, log-rank test p = 0.089). CONCLUSIONS: Despite having end-stage liver disease and advanced cardiothoracic disorders and experiencing a complex intraoperative course, cCSLT patients had comparable 90-day survival to iLT patients. Comprehensive planning before transplant, optimal patient/donor selection, the multiple-team model, and meticulous intraoperative management are critical to the success of cCSLT.

Does A Low 6-Minute Walk Distance Predict Elevated Postoperative Troponin?

Our study of 100 major vascular and renal transplant patients evaluated the 6-minute walk test (6MWT) as an indicator of perioperative myocardial injury, using troponin as a marker. Using logistic regression and the area under the receiving operator characteristic curve, we compared the 6MWT to the Revised Cardiac Risk Index and metabolic equivalents. Only the 6MWT was associated with elevated postoperative troponins (95% CI, 0.98-0.99). However, the 6MWT area under the receiving operator characteristic curve (0.71 [95% CI, 0.57-0.85]) was not different from the Revised Cardiac Risk Index (P = .23) or metabolic equivalents (P = .14). The 6MWT may have a role in cardiac risk stratification in the perioperative setting.

Three Pillars of Recovery After Aneurysmal Subarachnoid Hemorrhage: A Narrative Review.

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurologic disease with high mortality and disability. There have been global improvements in survival, which has contributed to the prevalence of patients living with long-term sequelae related to this disease. The focus of active research has traditionally centered on acute treatment to reduce mortality, but now there is a great need to study the course of short- and long-term recovery in these patients. In this narrative review, we aim to describe the core pillars in the preservation of cerebral function, prevention of complications, the recent literature studying neuroplasticity, and future directions for research to enhance recovery outcomes following aSAH.

Acetabular cup stiffness and implant orientation change acetabular loading patterns.

Acetabular cup orientation has been shown to influence dislocation, impingement, edge loading, contact stress, and polyethylene wear in total hip arthroplasty. Acetabular implant stiffness has been suggested as a factor in pelvic stress shielding and osseous integration. This study was designed to examine the combined effects of acetabular cup orientation and stiffness and on pelvic osseous loading. Four implant designs of varying stiffness were implanted into a composite hemipelvis in 35° or 50° of abduction. Specimens were dynamically loaded to simulate gait and pelvic strains were quantified with a grid of rosette strain gages and digital image correlation techniques. Changes in the joint reaction force orientation significantly altered mean acetabular bone strain values up to 67%. Increased cup abduction resulted in a 12% increase along the medial acetabular wall and an 18% decrease in strain in inferior lateral regions. Imbalanced loading distributions were observed with the stiffer components, resulting in higher, more variable, and localized surface strains. This study illustrates the effects of cup stiffness, gait, and implant orientation on loading distributions across the implanted pelvis.

High initial stability in porous titanium acetabular cups: a biomechanical study.

Initial stability with limited micromotion in uncemented total hip arthroplasty acetabular components is essential for bony attachment and long-term biomechanical fixation. This study compared porous titanium fixation surfaces to clinically established, plasma-sprayed designs in terms of interface stability and required seating force. Porous plasma-sprayed modular and metal-on-metal (MOM) cups were compared to a modular, porous titanium designs. Cups were implanted into polyurethane blocks with1-mm interference fit and subsequently edge loaded to failure. Porous titanium cups exhibited 23% to 65% improvement in initial stability when compared to plasma-sprayed cup designs (P=.01): a clinically significant increase, based on experience and prior literature. The results of this study indicate increased interface stability in porous titanium-coated cups without significantly increasing the necessary force and energy required for full seating.

Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention.

Dental caries (tooth decay) is the most prevalent human disease caused by oral biofilms, affecting nearly half of the global population despite increased use of fluoride, the mainstay anticaries (tooth-enamel protective) agent. Recently, an FDA-approved iron oxide nanozyme formulation (ferumoxytol, Fer) has been shown to disrupt caries-causing biofilms with high specificity via catalytic activation of hydrogen peroxide, but it is incapable of interfering with enamel acid demineralization. Here, we find notable synergy when Fer is combined with stannous fluoride (SnF 2 ), markedly inhibiting both biofilm accumulation and enamel damage more effectively than either alone. Unexpectedly, our data show that SnF 2 enhances the catalytic activity of Fer, significantly increasing reactive oxygen species (ROS) generation and antibiofilm activity. We discover that the stability of SnF 2 (unstable in water) is markedly enhanced when mixed with Fer in aqueous solutions without any additives. Further analyses reveal that Sn 2+ is bound by carboxylate groups in the carboxymethyl-dextran coating of Fer, thus stabilizing SnF 2 and boosting the catalytic activity. Notably, Fer in combination with SnF 2 is exceptionally effective in controlling dental caries in vivo , preventing enamel demineralization and cavitation altogether without adverse effects on the host tissues or causing changes in the oral microbiome diversity. The efficacy of SnF 2 is also enhanced when combined with Fer, showing comparable therapeutic effects at four times lower fluoride concentration. Enamel ultrastructure examination shows that fluoride, iron, and tin are detected in the outer layers of the enamel forming a polyion-rich film, indicating co-delivery onto the tooth surface. Overall, our results reveal a unique therapeutic synergism using approved agents that target complementary biological and physicochemical traits, while providing facile SnF 2 stabilization, to prevent a widespread oral disease more effectively with reduced fluoride exposure.

Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention.

Dental caries is the most common human disease caused by oral biofilms despite the widespread use of fluoride as the primary anticaries agent. Recently, an FDA-approved iron oxide nanoparticle (ferumoxytol, Fer) has shown to kill and degrade caries-causing biofilms through catalytic activation of hydrogen peroxide. However, Fer cannot interfere with enamel acid demineralization. Here, we show notable synergy when Fer is combined with stannous fluoride (SnF2), markedly inhibiting both biofilm accumulation and enamel damage more effectively than either alone. Unexpectedly, we discover that the stability of SnF2 is enhanced when mixed with Fer in aqueous solutions while increasing catalytic activity of Fer without any additives. Notably, Fer in combination with SnF2 is exceptionally effective in controlling dental caries in vivo, even at four times lower concentrations, without adverse effects on host tissues or oral microbiome. Our results reveal a potent therapeutic synergism using approved agents while providing facile SnF2 stabilization, to prevent a widespread oral disease with reduced fluoride exposure.

International Liver Transplantation Society/Society for Advancement of Transplant Anesthesia Consensus Statement on Essential Attributes of a Liver Transplant Anesthesiologist.

BACKGROUND: We sought to establish consensus on the essential skills, knowledge, and attributes that a liver transplant (LT) anesthesiologist should possess in a bid to help guide the further training process. METHODS: Consensus was achieved via a modified Delphi methodology, surveying 15 identified international experts in the fields of LT anesthesia and critical care. RESULTS: Key competencies were identified in preoperative management and optimization of a potential LT recipient; intraoperative management, including hemodynamic monitoring; coagulation and potential crisis management; and postoperative intensive and enhanced recovery care. CONCLUSIONS: This article provides an essential guide to competency-based training of an LT anesthesiologist.

Incorporating a health policy practicum in a graduate training program to prepare advanced practice nursing health services researchers.

Health services research benefits from the active engagement of researchers and policy makers from generation through to application of research-based knowledge. One approach to help graduate students learn about the policy world is through participation in a policy practicum. This is an opportunity to work for a defined period of time in a setting where policy decisions are made. This article focuses on the integration of the policy practicum into graduate nursing education for advanced practice nurses. Ten graduate students and two postdoctoral fellows who had recently completed their practicums and three policy makers who had recently supervised students in provincial, federal, and international practicum projects were invited to submit a narrative about the experience. Based on qualitative analysis of the narratives, this article outlines objectives of the practicum, the policy practicum journey, student learning, and finally, the benefits and challenges of the experience.

Intraoperative High Tidal Volume Ventilation and Postoperative Acute Respiratory Distress Syndrome in Liver Transplant.

BACKGROUND: Mechanical ventilation plays an important role in perioperative management and patient outcomes. Although mechanical ventilation with high tidal volume (HTV) is injurious in patients in the intensive care unit, the effects of HTV ventilation in patients undergoing liver transplant (LT) has not been reported. The aim of this study was to determine if intraoperative HTV ventilation was associated with the development of acute respiratory distress syndrome (ARDS). METHODS: Patients undergoing LT between 2013 and 2018 at a tertiary medical center were reviewed. The tidal volume was recorded at 3 time points: after anesthesia induction, before liver reperfusion, and at the end of surgery. Patients were divided into 2 groups: HTV (>10 mL/kg predicted body weight [pBW]) and non-HTV (≤10 mL/kg pBW). The 2 groups were compared. Independent risk factors were identified by multivariable logistic models. RESULTS: Of 780 LT patients, 85 (10.9%) received HTV ventilation. Female sex and greater difference between actual body weight and pBW were independent risk factors for HTV ventilation. Patients who received HTV ventilation had a significantly higher incidence of ARDS (10.3% vs 3.9%; P = .01) than those who received non-HTV ventilation. CONCLUSIONS: In this retrospective study, we showed that HTV ventilation during LT was common and was associated with a higher incidence of ARDS. Therefore, tidal volume should be carefully selected during LT surgery. More studies using a prospective randomized controlled design are needed.

Recommendations From the Society for the Advancement of Transplant Anesthesiology Fellowship Committee: Core Competencies and Milestones for the Kidney/Pancreas Component of Abdominal Organ Transplant Anesthesia Fellowship.

The Society for the Advancement of Transplant Anesthesia (SATA) is dedicated to improving patient care in all facets of transplant anesthesia. The anesthesia fellowship training recommendations for thoracic transplantation (heart and lungs) and part of the abdominal organ transplantation (liver) have been presented in previous publications. The SATA Fellowship Committee has completed the remaining component of abdominal transplant anesthesia (kidney/pancreas) and has assembled core competencies and milestones derived from expert consensus to guide the education and overall preparation of trainees providing care for kidney/pancreas transplant recipients. These recommendations provide a comprehensive approach to pre-operative evaluation, vascular access procedures, advanced hemodynamic monitoring, assessment of coagulation and metabolic abnormalities, operative techniques, and post-operative pain control. As such, this document supplements the current liver/hepatic transplant anesthesia fellowship training programs to include all aspects of "Abdominal Organ Transplant Anesthesia" recommended knowledge.

Metal backing significantly decreases tibial strains in a medial unicompartmental knee arthroplasty model.

Clinical success of unicompartmental knee arthroplasty (UKA) is on the rise and is dependent on multiple patient, implant, and surgical factors. Tibial subsidence has been clinically reported as a cause of failure in UKA with an all-polyethylene tibial design in the absence of metal backing, yet the role of metal backing UKA tibial components on tibial loading is not fully understood. In this study, composite tibiae were implanted with medial all-polyethylene fixed-bearing or metal-backed UKA tibial components and a 1.5-kN load applied in 3 different contact positions simulating femoral translation during gait. All-polyethylene tibial components exhibited significantly higher strain measurements in each femoral position. This study demonstrates the role that metal backing plays on generating an even loading distribution while diminishing the development localized regions of excessive loading across the medial tibial cortex.

Major Thromboembolic Complications in Liver Transplantation: The Role of Rotational Thromboelastometry and Cryoprecipitate Transfusion.

BACKGROUND: Although hemorrhage is a major concern during liver transplantation (LT), the risk for thromboembolism is well recognized. Implementation of rotational thromboelastometry (ROTEM) has been associated with the increased use of cryoprecipitate; however, the role of ROTEM-guided transfusion strategy and cryoprecipitate administration in the development of major thromboembolic complications (MTCs) has never been documented. METHODS: We conducted a study on patients undergoing LT before and after the implementation of ROTEM. We defined MTC as intracardiac thrombus, pulmonary embolism, hepatic artery thrombosis, and ischemic stroke in 30 d after LT. We used a propensity score to match patients during the 2 study periods. RESULTS: Among 2330 patients, 119 (4.9%) developed MTC. The implementation of ROTEM was significantly associated with an increase in cryoprecipitate use (1.1 ± 1.1 versus 2.9 ± 2.3 units, P < 0.001) and MTC (4.2% versus 9.5%, P < 0.001). Further analysis demonstrated that the use of cryoprecipitate was an independent risk factor for MTC (odds ratio 1.1, 95% confidence interval 1.04-1.24, P = 0.003). Patients with MTC had significantly lower 1-y survival. CONCLUSIONS: Our study suggests that the implementation of ROTEM and the use of cryoprecipitate play significant roles in the development of MTC in LT. The benefits and risks of cryoprecipitate transfusion should be carefully evaluated before administration.

A comparison in proximal tibial strain between metal-backed and all-polyethylene anatomic graduated component total knee arthroplasty tibial components.

Loading in total knee arthroplasty (TKA) is multifactorial and dependent on alignment, ligament balance, patient, and implant factors. Abnormal loading has been linked to clinical failure; however, the respective contribution of each factor to failure is not well known. This study defined the effect of metal backing on loading patterns in the proximal tibia. Composite tibiae were implanted with metal-backed and all-polyethylene Anatomic Graduated Component TKA tibial components (Biomet, Inc, Warsaw, Ind) and coated with photoelastic material allowing full-field dynamic strain quantification. In simulated varus loading distributions, significant increases in measured strain were observed ranging from 40% to 587% for all-polyethylene vs metal-backed tibial components. Higher observed strains in the proximal tibia observed with all-polyethylene tibial components could possibly explain increased clinical failure rates observed with this TKA design.

The effects of bone resection depth and malalignment on strain in the proximal tibia after total knee arthroplasty.

The clinical significance of tibial resection depth in total knee arthroplasty (TKA) is not clearly understood. The purpose of this study was to quantify the effect of tibial resection depth in TKA on tibial loading. Tibiae were coated with a photoelastic resin enabling full-field dynamic shear strain quantification in the tibial metaphysis during TKA loading. A standard resection level (5 mm) was compared to a resection level 15 mm distal to the joint line. Both had appropriate-sized tibial components. With 15 mm of tibial resection, strains increased up to 281% in the proximal and peripheral regions of the tibia during neutral loading and up to 315% anteriorly and 197% peripherally during varus loading. Distal resection levels result in significant smaller component size and relatively posterior and peripheral displacement of the implant. Changes in loading patterns in specimens with increased tibial resection depths have not previously been described.

Mechanical stability of novel highly porous metal acetabular components in revision total hip arthroplasty.

Highly porous metal acetabular components have emerged for revision hip arthroplasty. However, superior mechanical stability over traditional cementless components has not been demonstrated. Three different cementless acetabular components, including 2 highly porous tantalum designs, were inserted into hemipelvis specimens with a superolateral defect. Mechanical testing was performed to failure using a servohydraulic testing machine. The porous tantalum designs exhibited superior stability over the traditional cementless implant (P < .05). There was no difference in mechanical stability between the rigid modular tantalum shell and the more flexible revision tantalum shell (P > .46). In acetabular revision, highly porous tantalum acetabular components provide superior mechanical stability. However, these results suggest that improved frictional resistance is a more important design feature over implant flexibility with this particular implant.

Does ischial screw fixation improve mechanical stability in revision total hip arthroplasty?

Ischial screw fixation, albeit technically challenging, is postulated to provide additional mechanical stability in revision total hip arthroplasty (THA). Hemipelvis specimens were prepared to simulate revision THA, and an acetabular component with supplemental screw fixation was implanted. Three configurations were tested: 2 dome screws alone, 2 dome screws plus an additional screw within the dome, and 2 dome screws plus an ischial screw. Force displacement data were acquired during mechanical testing. An increase in mechanical stability was observed in acetabular components with supplemental screw fixation into either the posterior column or ischium (P≤.031) compared to isolated dome fixation. In addition, supplemental ischial screw fixation may provide a modest advantage over a screw placed posteroinferiorly within the acetabular dome during revision THA.

Effects of femoral component size on proximal tibial strain with anatomic graduated components total knee arthroplasty.

Survivorship in total knee arthroplasty (TKA) is multifactorial and dependent upon alignment, ligament balance, patient characteristics, and implant factors. The contribution of each factor leading to implant loosening is not well known. This study defined the effect of femoral component sizing relative to tibial size on loading patterns in the proximal tibia. Changes in strain were measured in tibiae implanted with appropriately sized metal-backed tibial components loaded with 2 sizes of femoral components. Significant increases of shear strain up to 126% were measured in peripheral regions of the tibia when loaded with a larger vs a smaller femoral component. Increased peripheral loading in the proximal tibia could predispose to a higher risk of cancellous overload and failure. Limiting stress concentrations in the periphery of the proximal tibia by considering sizing relationships between femoral and tibial components may decrease osseous strains and the likelihood of bony overload in TKA.