Detalhe da pesquisa
1.
Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aß production and related pathology in a mouse model of Alzheimer's disease.
J Neurochem
; 156(5): 658-673, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33278025
2.
Dronedarone Modulates M1 and M3 Muscarinic Receptors with Subtype Selectivity, Functional Selectivity, and Probe Dependence.
Pharmacology
; 99(3-4): 128-138, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27992867
3.
Preclinical PET Neuroimaging of [11C]Bexarotene.
Mol Imaging
; 152016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27553293
4.
Identification of the antiarrhythmic drugs amiodarone and lorcainide as potent H3 histamine receptor inverse agonists.
J Pharmacol Exp Ther
; 348(1): 116-24, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24204014
5.
On the discovery and development of pimavanserin: a novel drug candidate for Parkinson's psychosis.
Neurochem Res
; 39(10): 2008-17, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24682754
6.
Bexarotene prodrugs: targeting through cleavage by NQO1 (DT-diaphorase).
Bioorg Med Chem Lett
; 24(8): 1944-7, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24666648
7.
Should inverse agonists be defined by pharmacological mechanism or clinical effect?
CNS Spectr
; 24(4): 349-351, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30890194
8.
The protease activated receptor 2 (PAR2) polymorphic variant F240S constitutively activates PAR2 receptors and potentiates responses to small-molecule PAR2 agonists.
J Pharmacol Exp Ther
; 347(3): 697-704, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24078870
9.
Pimavanserin reverses multiple measures of anxiety in a rodent model of post-traumatic stress disorder.
Eur J Pharmacol
; 939: 175437, 2023 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36502961
10.
The impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the P301L/COMT- and rTg(P301L)4510 mouse models of Alzheimer's disease.
Alzheimers Dement (N Y)
; 8(1): e12247, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35128032
11.
Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor.
J Pharmacol Exp Ther
; 337(1): 275-84, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21239511
12.
I. In vivo evidence for partial agonist effects of (-)-OSU6162 and (+)-OSU6162 on 5-HT2A serotonin receptors.
J Neural Transm (Vienna)
; 118(11): 1511-22, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21874578
13.
II. In vitro evidence that (-)-OSU6162 and (+)-OSU6162 produce their behavioral effects through 5-HT2A serotonin and D2 dopamine receptors.
J Neural Transm (Vienna)
; 118(11): 1523-33, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21866391
14.
Relevance of 5-HT2A Receptor Modulation of Pyramidal Cell Excitability for Dementia-Related Psychosis: Implications for Pharmacotherapy.
CNS Drugs
; 35(7): 727-741, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34224112
15.
Pimavanserin Promotes Trophic Factor Release and Protects Cultured Primary Dopaminergic Neurons Exposed to MPP+ in a GDNF-Dependent Manner.
ACS Chem Neurosci
; 12(12): 2088-2098, 2021 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34032411
16.
Discovery of a class of calcium sensing receptor positive allosteric modulators; 1-(benzothiazol-2-yl)-1-phenylethanols.
Bioorg Med Chem Lett
; 20(19): 5918-21, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20727747
17.
Optimization of isochromanone based urotensin II receptor agonists.
Bioorg Med Chem
; 18(13): 4844-54, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20570157
18.
Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis.
Bioorg Med Chem Lett
; 19(6): 1729-32, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19230660
19.
Inverse agonists of the 5-HT2A receptor reduce nicotine withdrawal signs in rats.
Neurosci Lett
; 713: 134524, 2019 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31585211
20.
Pharmacology of N-desmethylclozapine.
Pharmacol Ther
; 115(2): 223-31, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17583355