Detalhe da pesquisa
1.
Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor.
Gynecol Oncol
; 172: 65-71, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36958197
2.
RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature
; 526(7574): 583-6, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26466569
3.
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.
N Engl J Med
; 373(5): 428-37, 2015 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26222558
4.
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Nature
; 467(7315): 596-9, 2010 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20823850
5.
Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proc Natl Acad Sci U S A
; 110(14): 5689-94, 2013 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23493555
6.
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.
N Engl J Med
; 366(3): 207-15, 2012 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-22256804
7.
Comparative Genomics of Six Lytic Bacillus subtilis Phages from the Southwest United States.
Phage (New Rochelle)
; 3(3): 171-178, 2022 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793550
8.
Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
JAMA Oncol
; 7(9): 1343-1350, 2021 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34236401
9.
PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors.
Clin Exp Med
; 19(2): 201-210, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30523507
10.
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Nat Commun
; 10(1): 3758, 2019 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31434879
11.
Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway.
Mol Cell Biol
; 25(20): 8834-43, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16199863
12.
Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer.
Pain
; 156(9): 1692-1702, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25993548
13.
Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.
Cancer Discov
; 5(6): 668-79, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25847190
14.
Noninvasive muscle oxygenation to guide fluid resuscitation after traumatic shock.
Surgery
; 135(6): 662-70, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15179373
15.
Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy.
Pigment Cell Melanoma Res
; 26(6): 845-51, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23890088
16.
The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis.
Appl Environ Microbiol
; 72(7): 5043-51, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16820504
17.
Abl tyrosine kinases are required for infection by Shigella flexneri.
EMBO J
; 22(20): 5471-9, 2003 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14532119
18.
Building a better fluid for emergency resuscitation of traumatic brain injury.
J Trauma
; 57(3): 547-54, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15454801