[Possibilities of correcting some metabolic disorders in experimental endotoxic shock by treatment with a combination of alpha-lipoic acid and epsilon aminocaproic acid]. / Posibilitati de corectare a unor tulburari metabolice din socul endotoxic experimental prin asociatia acid alpha-lipoic--acid epsilon-aminocaproic

Alpha-Lipoic acid associated with xi-aminocaproic acid proves to have a protector effect in the posttreatment of endotoxinic shock in rabbits, produced by the administration of E. coli O111, in doses of 1.5 mg/kg body weight. This effect was observed when administered early in the stage of energy privation, and was manifested by a longer survival, diminution of lactacidemia and protection of labile phosphate reserves.

[Clinical and biological aspects of chronic brucellosis]. / Delimitari clinice si biologice în bruceloza cronica

The present study refers to 53 cases of chronic brucellosis admitted to the clinic or followed up in an out-patient unit for ten years (1962-1971). There was a total of 946 days in hospital and 1688 days of occupational disability, about 40% of the patients necessitating repeated hospitalization because of the relapsing course of the disease. This group of cases presented the classical dominant features of an occupational anthropozoonoses (90.5%). Elements of visceral and tissular pathology, obviously conditioned in their structure by the stage of the disease, were found in cardiovascular, hepatic, nervous, osteoarticular, orchitic, ocular, cutaneous localizations, etc. Their associated character particularize the polyvisceral forms. The immunopathology of chronic brucellosis is marked by its dynamics and frequently dissociated character of the sero-allergic diagnostic reactions. Blood proteins behave unequally (hypoalbuminemia, hyperalpha1-, hyperalpha2- and hypergammaglobulinemia). There is still debate about the terapeutic attempts, although sigmamycin associated with cortisone derivatives reduce or temporize the relapsing evolution, opening up new therapeutical perspectives.