[Fibrinolytic therapy of patients with pulmonary artery thromboembolism by tissue plasminogen activator and streptokinase preparations]. / Fibrinoliticheskaia terapiia bol'nykh s tromboémboliei legochnoi arterii tkanevym aktivatorom plazminogena i preparatami streptokinasy.

Changes in clinical and hemodynamic indices, hemostatic system during therapy with plasminogen tissue activator and streptokinase drugs were studied in 49 patients with massive and submassive forms of pulmonary thromboembolism. Conduction of fibrinolytic therapy with plasminogen tissue activator vs streptokinase produced more marked and rapid change in the main hemodynamic parameters which characterized blood recovery in pulmonary artery. A correlation was revealed between the change in hemostatic system after thrombolytic therapy and development of hemorrhagic complications. Preferable introduction of plasminogen tissue activator is shown when thromboemboli locate in the trunk or in both main pulmonary arteries and in the presence of an occlusive lesion in lobular arteries.

[Human cardiac activity during the 1st hours and days of exposure to antiorthostatic hypokinesia (according to the results of echocardiography)]. / Deiatel'nost' serdtsa cheloveka v pervye chasy i sutki prebyvaniia v usloviiakh antiortostaticheskoi gipokinezii (po dannym ékhokardiografii).

Six healthy volunteers (aged 19-24) were exposed to head-down tilt (at-10 degrees) for 7 days. The study revealed phasic changes of intracardiac circulation and the pump function which were not accompanied by contractility disorders. On the whole, the changes represented a manifestation of cardiovascular adaptation to hemodynamic shifts that are typical of this type of simulated weightlessness. The echocardiographic parameters varied similarly during the head-down tilt test and the joint Soviet-French experiment onboard Salyut-7.