Detalhe da pesquisa
1.
Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists.
Bioorg Med Chem Lett
; 25(10): 2041-5, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25890801
2.
Essential role of TAK1 in regulating mantle cell lymphoma survival.
Blood
; 120(2): 347-55, 2012 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22649101
3.
Towards the next generation of dual Bcl-2/Bcl-xL inhibitors.
Bioorg Med Chem Lett
; 24(14): 3026-33, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24881567
4.
The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis.
Front Mol Biosci
; 8: 715765, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34513923
5.
AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.
Clin Cancer Res
; 26(24): 6535-6549, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32988967
6.
Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors.
Bioorg Med Chem Lett
; 18(24): 6486-9, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18986805
7.
Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.
Bioorg Med Chem Lett
; 18(20): 5487-92, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18815031
8.
AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis.
Clin Cancer Res
; 13(12): 3682-8, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17575233
9.
AZ703, an imidazo[1,2-a]pyridine inhibitor of cyclin-dependent kinases 1 and 2, induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent kinase 9.
Cancer Res
; 66(1): 435-44, 2006 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16397259
10.
Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
ACS Chem Biol
; 13(11): 3131-3141, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30335946
11.
A phase I pharmacodynamic study of the effects of the cyclin-dependent kinase-inhibitor AZD5438 on cell cycle markers within the buccal mucosa, plucked scalp hairs and peripheral blood mononucleocytes of healthy male volunteers.
Cancer Chemother Pharmacol
; 60(4): 479-88, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17143601
12.
The cellular phenotype of AZ703, a novel selective imidazo[1,2-a]pyridine cyclin-dependent kinase inhibitor.
Mol Cancer Ther
; 5(3): 655-64, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16546980
13.
Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity.
Oncotarget
; 8(41): 69219-69236, 2017 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29050199
14.
Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum.
Oncotarget
; 8(59): 99237-99244, 2017 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29245897
15.
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J Med Chem
; 60(10): 4386-4402, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28485934
16.
Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma.
Oncotarget
; 7(8): 9163-74, 2016 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26824321
17.
Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.
J Med Chem
; 58(17): 7057-75, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26291341
18.
Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma.
Oncotarget
; 5(13): 4990-5001, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24970801
19.
Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol.
ACS Chem Biol
; 8(3): 643-50, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23272696
20.
Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J Med Chem
; 60(14): 6459, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28714680