Familial dilated cardiomyopathy and spontaneous ventricular arrhythmias.

Two members of a family with (autosomal dominant) dilated cardiomyopathy and symptomatic short-lasting ventricular tachyarrhythmias were each treated with an ICD in the course of their disease. One patient had an episode of torsades de pointes induced by amiodarone, and the ICD failed to recognize some events. Cardiac arrest recurred in this setting. Treatment with bisoprolol was helpful in maintaining an acceptable functional status and in preventing multiple shocks until transplantation became mandatory. Bisoprolol was not tolerated by the second patient, who had several episodes of syncope because of nonsustained ventricular tachycardia. His functional course went downhill fast, and he received a heart transplantation 16 months after implantation of an ICD, which had not delivered any shocks, in spite of one symptomatic short ventricular tachycardia.

Tissue factor as the main activator of the coagulation system during cardiopulmonary bypass.

OBJECTIVE: This study investigates the influence of foreign material and blood aspirated from nonvascular structures on activation of coagulation, hemolysis, and blood loss. METHODS: The series comprises 3 randomized groups (groups C, S, and S+P) of 10 patients undergoing routine coronary artery bypass grafting with cardiopulmonary bypass. In group C, the control group, all aspirated blood was returned into the circulation. In group S suction blood was discarded, whereas group S+P was identical to group S, with surfaces coated with phosphorylcholine. Plasma concentrations of beta-thromboglobulin, thrombin generation, haptoglobin, and free hemoglobin, as well as blood loss, were measured. RESULTS: A steady increase in free plasma hemoglobin, as well as an increased generation of thrombin, was noticed in group C. Moreover, a close correlation (r = 0.916) between the generation of thrombin and its inhibition (thrombin-antithrombin complexes) was observed. Platelets were clearly activated in group C and, to a lesser extent, in group S. In contrast, platelet activation in group S+P was negligible, resulting in a 30% decrease in blood loss (P =.05). CONCLUSIONS: Aspirated blood contaminated by tissue contact is the most important activator of the coagulation system and the principal cause of hemolysis during cardiopulmonary bypass. Contact with a foreign surface is not a main variable in the procoagulant effect of bypass. Mimicking the outer cell membrane structure resulted in decreased platelet activation and decreased blood loss.

Tricuspid valve replacement: postoperative and long-term results.

A series of 146 consecutive patients who underwent tricuspid valve replacement at the University Brugmann Hospital between 1967 and 1987 was reviewed. Mean age at operation was 51.4 years (+/- 12.1 years). Different types of prostheses were implanted including porcine and bovine pericardial bioprostheses and older and bileaflet mechanical valves. Most patients were severely disabled by their cardiac disease before operation, with 30.1% in New York Heart Association functional class III and 69.9% in class IV. Operative mortality and hospital mortality rates (30 days) were high (16.4%). Incremental risk factors for hospital death included icterus (p < 0.005), preoperative hepatomegaly (p = 0.012), and New York Heart Association functional class IV (p = 0.013). Multivariate analysis only selected preoperative icterus (p < 0.01) as being independently significantly related to hospital mortality. The hospital survivors were followed up for a median of 94 months. A complete follow-up was available for all patients except two for 30 months or more. At 30 months the only two significant parameters were the type of myocardial protection (p = 0.024) and the year of operation (before 1977 or after [precardioplegia era or after], p = 0.011). There were 70 late deaths during the entire follow-up period. The univariate (log-rank statistics) incremental risk factor for late death was the type of tricuspid prosthesis (Smeloff-Cutter and Kay-Shiley versus St. Jude Medical versus bioprosthesis) (p = 0.04). A trend was observed for the type of operative myocardial protection (normothermia and coronary perfusion) (p = 0.06) and preoperative New York Heart Association functional class IV (p = 0.055). Actuarial survival was 74% at 60 months and 23.4% at 180 months. Cumulative follow-up added up to 1015 patient-years. In a more detailed analysis of the effect on survival of the type of tricuspid prosthesis, a significant difference was observed between the bioprostheses and some older mechanical prostheses (Smeloff-Cutter and Kay-Shiley) (p = 0.04) but not between the bioprostheses and the bileaflet valves (p = 0.15). When the follow-up period was stratified according to less than 7 years and more than 7 years of follow-up, no difference was observed for the first period, but for the late follow-up the new mechanical prostheses did better than the bioprostheses (p = 0.05), suggesting a degradation of the bioprostheses after 7 years and favoring mechanical prostheses for those patients with a good long-term prognosis.

Feasibility of a pumpless extracorporeal respiratory assist device.

BACKGROUND: Our study evaluated the efficacy and feasibility of a pumpless respiratory assist device and determined its capacity for carbon dioxide removal. METHODS: In five adult pigs the left femoral vein and artery were cannulated with a 20F cannula and connected to a low-pressure hollow-fiber artificial lung. After we had obtained baseline values of mean arterial pressure, cardiac output, and blood flow across the artificial lung, the mean arterial pressure was reduced 20% and 40% relative to baseline; in a second phase, it was raised 20% and 40. Cardiac output and artificial lung flow were simultaneously recorded. We determined the carbon dioxide removal capacity of the artificial lung by gradually increasing the arterial partial carbon dioxide tension of the animal. RESULTS: An increase of 10 mm Hg in mean arterial pressure resulted in an increase of flow of 0.14 L/min. The mean pressure drop across the artificial lung was measured at 17 +/- 9 mm Hg. The shunt flow over the artificial lung varied between 14 and 25% of the cardiac output of the animal. Depending on inlet conditions, carbon dioxide removal by the artificial lung was between 62 +/- 22 mL/L/min and 104 +/- 25 mL/L/min. CONCLUSIONS: A pumpless respiratory assist device can remove a significant proportion of the metabolic carbon dioxide production. However, adequate mean arterial pressure is mandatory to maintain sufficient flow across the device. The technique seems attractive because of its simplicity and can be used in acute lung injury in conjunction of apneic oxygenation for prolonged respiratory support.

Aortocolic fistula caused by an ingested chicken bone.

Primary aortocolic fistulas are a rare but lethal complication of aortic or iliac aneurysms. A case of fistula between a nonaneurysmal aortic bifurcation and sigmoid colon caused by an ingested chicken bone is presented. This cause of rectal bleeding, which has never been described, might have been suspected after careful examination of abdominal x-ray films. Surgical management included removal of the foreign body and primary repair of the colonic and aortic rent and appeared to be adequate.

Use of internal mammary artery for emergency grafting after failed coronary angioplasty.

Of 929 consecutive patients who underwent percutaneous transluminal coronary angioplasty over a 36-month period, 32 (3.4%) had emergency coronary artery bypass grafting for angioplasty failure. Twenty-two patients (69%) were hemodynamically stable (stable group), and 10 (31%) were unstable (unstable group) before emergency bypass. In the unstable group, the interval between failed angioplasty and opening of the grafts or end of extracorporeal circulation was significantly shorter (p < 0.001 and p < 0.002, respectively) and significantly more grafts per patient were performed (p < 0.05) than in the stable group. Twenty-seven patients (84%) received at least one internal mammary artery graft, independent of their hemodynamic condition. In 11 culprit left anterior descending arteries, the internal mammary artery graft was supplemented by a saphenous vein graft to the same territory, especially in the unstable group. There were no hospital deaths. Postoperatively, the incidence of myocardial infarction (p < 0.005) and the use of antiarrhythmics (p < 0.0001) were increased and length of stay tended to be longer in the unstable compared with the stable group. The use of a reperfusion catheter had no influence on clinical outcome, except for a significantly reduced postoperative use of antiarrhythmics (p < 0.05). The internal mammary artery can be used in emergency coronary artery bypass grafting after failed percutaneous transluminal coronary angioplasty, without hospital mortality and with acceptable morbidity, especially in hemodynamically stable patients.

Surgical treatment of impending paradoxical embolism through patent foramen ovale.

We describe the case of a patient with deep venous thrombosis who had cerebral and extremity paradoxical emboli and an intracardiac thrombus crossing a patent foramen ovale identified by echocardiography. He was treated successfully with immediate intracardiac embolectomy and closure of the patent foramen ovale.

Valve replacement with the ATS open pivot bileaflet prosthesis.

OBJECTIVE: We sought to evaluate the ATS open pivot bileaflet valve with respect to haemodynamics and thromboembolism. METHODS: We prospectively studied 200 consecutive patients aged 13-80 years. One hundred and nineteen aortic, 103 mitral and 11 tricuspid valves were replaced in 172 single, 23 double and 5 triple valve procedures. Thirty-eight were re-operations and 51 underwent coronary bypass. Transvalvular gradients were determined by transoesophageal and transthoracic echocardiography. Patients were followed for 12 months to 3 years. RESULTS: There were four hospital (2%) and three late deaths, each non-valve related. Two patients were reoperated for partial valve dehiscence. One aortic reoperation patient suffered a potential transient thromboembolic event. One tricuspid prosthesis thrombosed after anticoagulation was discontinued but thrombolysis resolved this problem. There were no other thromboembolic events. Valve gradients were equivalent or better than those for other bileaflet valves. CONCLUSIONS: The ATS valve has excellent haemodynamic characteristics and a very low thromboembolic rate, probably related to the convex self-washing hinge mechanism. Consequently, we have reduced anticoagulant levels to INR (international normalised ratio) 1.5 to 2.0 for aortic valve patients in sinus rhythm. Early experience suggests that the ATS valve functions well in the tricuspid position.

Stentless or stented aortic valve implants in elderly patients?

OBJECTIVE: To assess differences in indication and mid-term results between stentless and stented procedures in elderly patients, we followed aortic valve patients over a period of 5 years. METHODS: In a consecutive series of 154 elderly aortic patients in regular sinus rhythm from 1992 to 1997, we inserted 103 stentless (Toronto SPVTM, St Jude Medical Inc., St Paul, Minneapolis, MN) and 51 stented (Carpentier-Edwards supra annular porcine, Baxter Inc., Irvine, CA) bioprostheses in the aortic position. RESULTS: All 154 patients seemed preoperatively eligible for a stentless procedure. Mean age was 74.8 years (range 67-86 years) with a majority of female patients. The surgeon's (in)experience, major dilatation or calcifications of the ascending aorta and aberrant coronary anatomy were the most common reasons for drawback from the stentless procedure (51/154 patients). Aortic clamp time was significantly higher in the stentless vs. stented group (70 vs. 57 min, P < 0.0001). The large average 25.3 mm size of the stentless prostheses (vs. 23.7 mm stented) stands in full contrast with the low mean body surface area of 1.68 m2 (vs. 1.70 m2) of the patients. We encountered. respectively. 5 and 2 hospital-deaths (P = n.s.). The follow-up period ranged from 6 to 66 months and was 97% complete, yielding, respectively, 302 and 139 patient-years. Survival (Kaplan-Meier method) was statistically higher in favor of the stentless procedures (log rank: P = 0.03). All survivors progressed markedly to a mean postoperative NYHA class 1.3 respectively, 1.4 (vs. preop. 3.3 and 3.2). Echocardiographic transvalvular gradients compared favorable for the stentless group in the small under 25 mm valves (P = 0.02 for 23 mm sized valves between groups) with improved left ventricular function and a significant decrease of left ventricular end diastolic diameter (LVEDD 48.0 vs. 56.5 mm) at 1 year follow-up. Cusp calcifications on control echocardiography were detected earlier (beyond 3 years) in the stented group, without signs of early significant regurgitation or dysfunction in both groups, except for one patient necessitating re-operation. CONCLUSION: Although the implantation technique is much more demanding for stentless procedures, reflected by a longer aortic clamp-time, and remains impossible in some cases, elderly, small sized patients take full benefit of their large, non-obstructive prostheses.

The valve choice in tricuspid valve replacement: 25 years of experience.

This study reviews 146 consecutive patients who underwent tricuspid valve replacement (TVR) with 69 bioprostheses (porcine and bovine pericardial) and 77 mechanical ball, disc or bileaflet valves between 1967 and 1987. The mean age was 51.4 +/- 12.1 years. Preoperatively, 97% were in New York Heart Association (NYHA) functional class III or more and over 40% had undergone previous cardiac surgery. Hospital mortality was high (16.1%). Incremental risk factors for hospital death were preoperative icterus (P < 0.01), hepatomegaly (P = 0.02), NYHA functional class IV (P = 0.02) and male sex (P = 0.04) (univariate analysis). Ninety-eight percent of the hospital survivors were followed up for a mean of 92 months. Cumulative follow-up added up to 955 patient-years. There were 70 late deaths. The actuarial survival rate was 74% at 60 months and less than 25% at 14 years. Incremental risk factors for late death indicated by univariate analysis were the type of tricuspid prosthesis (Smel-off-Cutter and Kay-Shiley prostheses) (P = 0.04), the type of operative myocardial protection (normothermia and coronary perfusion) (P = 0.05) and preoperative NYHA functional class IV (P = 0.05). We conclude that TVR carries a high operative risk and poor long-term survival, both influenced by preoperative and perioperative variables. Bearing in mind the poor prognosis for TVR, we prefer a large-sized bioprosthesis, in view of its initial good durability and low risk of valve-related events. However, in patients with good life expectancy, a bileaflet mechanical prosthesis may be an acceptable alternative.

Comparison of auscultation, continuous wave Doppler imaging, intravenous digital subtraction angiography and conventional angiography in diagnosis of carotid artery disease.

The reliability of auscultation, continuous wave (CW) Doppler imaging, and intravenous digital subtraction angiography (IV DSA) in the assessment of carotid artery disease has been evaluated in comparison with conventional angiography in 30 patients. With auscultation, specificity and sensitivity for internal carotid artery (ICA) stenosis of 50% or more were 81% and 67% respectively. CW Doppler imaging detected ICA stenosis of 50% or more with a sensitivity of 83% and a specificity of 92% and ICA occlusion with a sensitivity of 60%. The specificity of IV DSA was 95% and the sensitivity for ICA stenosis of 50% or more and ICA occlusion were 75% and 100% respectively. Combining CW Doppler and IV DSA findings raised sensitivity for ICA stenosis of 50% or more and ICA occlusion to 89% and 100% respectively and specificity to 95%. The combination of CW Doppler and IV DSA is a safe and accurate test battery in the detection and categorization of carotid disease.

Group B streptococcal endocarditis mimicking mitral valve myxoma.

A patient with group B streptococcal endocarditis and large vegetations resembling mitral valve myxoma is described. Group B streptococcal endocarditis and the differential diagnosis of vegetations and cardiac tumors are briefly reviewed.

Heart transplantation after emergency coronary artery bypass for failed angioplasty.

We describe the case of a 48-year-old woman who required emergency coronary artery bypass grafting because of extensive dissection, cardiogenic shock, and ventricular fibrillation after failed percutaneous transluminal coronary angioplasty for stenosis of a proximal left anterior descending coronary artery. Despite maximal inotropic support and intra-aortic balloon pumping, the patient could not be weaned from cardiopulmonary bypass, and a left ventricular assist device was placed. After 2 days of postoperative circulatory support, during which her respiratory and renal functions declined and cardiac output remained negligible due to a massive myocardial infarction, she underwent successful orthotopic heart transplantation.

Diagnostic and therapeutic value of thoracotomy in advanced pulmonary neoplasms.

This study analyses retrospectively 100 consecutive thoracotomies performed for lung cancer before end 1986. Chest CT scan assessed mediastinal lymph node disease, chest wall invasion and mediastinal invasion, with an overall accuracy of 75, 93 and 91 per cent respectively; mediastinal lymph node disease was significantly more underestimated in the stage III group. Characteristics, type of surgical and adjuvant therapy and follow-up were analysed in the T3 (16 patients) and the N2 (18 patients) group. Complete resection was possible in only a minority of the cases: 3 in the T3 group and one in the N2 group. Of the T3 group, 3 patients have survived more than 3 years and 3 are actually still alive. Of the N2 group, only 2 patients are still alive. Most deaths were due to generalization of the disease.

Transaxillary thoracotomy for treatment of spontaneous pneumothorax.

This study reports the retrospective analysis of operative treatment of 20 cases of spontaneous pneumothorax during the last 4 years. Surgical indications included recurrence, recollapse of the lung on clamping the chest tube, nonexpansion of the lung despite adequate drainage or persistent air leak, and giant bulla. A transaxillary thoracotomy was used in all cases to treat sites of air leak and subpleural blebs by resection (14 cases) or oversutering (4 cases) combined with pleural abrasion (19 cases) or apical pleurectomy (1 case). This approach has met with excellent results without major morbidity or mortality.

Fibromuscular dysplasia of the internal carotid artery.

An observation on symptomatic fibromuscular dysplasia of the internal carotid artery, surgically treated by graduated internal dilatation is presented. Fibromuscular dysplasia is a segmental, nonatheromatous disease of small to medium-sized arteries, affecting mainly renal arteries. Involvement of the internal carotid artery is often an incidental angiographic finding in asymptomatic patients, but can be associated with specific neurologic symptoms requiring surgical treatment. The histopathologic character, the pathogenesis, the clinical manifestation, the diagnosis and the therapeutic possibilities of this affection are discussed.

Femorofemoral bypass grafting in high-risk patients.

A total of 37 extra-anatomic femorofemoral bypasses were inserted for severe unilateral iliac artery stenosis or a thrombosed graft limb of an aorto-bifemoral bifurcation graft. All patients were severely debilitated and at high risk for direct aorto-iliac reconstruction. 30% suffered severe claudication; 70% had ischemic restpain or trophic lesions. 43% died during a mean follow-up period of 17 months. This study demonstrates that the extra-anatomic femoro-femoral bypass procedure is an effective alternative therapeutic modality for high-risk patients with an acceptable operative mortality (5.4%) and morbidity to improve the quality of life.

Fasciitis necroticans.

Fasciitis necroticans (F.N.) is a rapidly progressing necrotizing process of subcutaneous tissue and fascia which results in large soft tissue defects and severe systemic toxicity. During the last five years nine patients with F.N. were admitted at our department of surgery. Antibiotic prophylaxis immediately after the eliciting trauma was associated with a significant delay in treatment. Early recognition and surgical treatment are the most important factors influencing survival.

Operative outcome of minimal access aortic valve replacement versus standard procedure.

BACKGROUND: to determine the advantages and/or risks of minimal access aortic valve replacement compared to standard sternotomy procedure. METHODS: from January 1997 to December 2001, 271 consecutive adult patients underwent isolated aortic valve replacement of which 174 underwent a minimal access procedure (Group 1) and 97 a standard procedure (Group 2). The preoperative variables of both groups were comparable. Retrospective analysis of postoperative outcome was performed. RESULTS: follow-up was complete and ranged from 6 months to 4 years. Overall in-hospital mortality was 3.3% (respectively 2.8 and 4.1%). No statistical difference was noted regarding operative time variables, mortality rate and hospital stay. There was a significant higher incidence of revision (p = 0.018) and late pericardial effusion (p = 0.022) in the minimal access group. Also trends were in favour of the standard group for incidence of postoperative pneumothorax and pericarditis constrictiva. CONCLUSIONS: minimal access aortic valve replacement is a safe and reliable technique, but carries the risk of incision-related morbidity. Proper patient selection and perioperative management is mandatory.

[Systematic research on an etiology in apparently primary deep venous thrombosis. Apropos of 59 cases]. / Recherche systématique d'une étiologie dans les thromboses veineuses profondes d'apparence primitive. A propos de 59 cas.

Primary deep vein thrombosis was confirmed by phlebography in 59 cases between Jan. 1981 and Jan. 1984 in the department of Cardiovascular Surgery of the Academic Hospital of the V.U.B. Brussels. Investigations conducted in all patients included blood and urine analyses, chest radiography, electrocardiogram, gynecologic or urologic examinations and abdominal and pelvic ultrasound imaging. Findings demonstrated one or more risk factors in 92% of cases, the principal ones being obesity, a history of thromboemboli and, in women, the use of oral contraceptives. Nine patients had cancer and 4 of these received combined surgery-chemotherapy. All cases of so-called primary deep vein thrombosis should be investigated routinely for risk factors, because of the need and possibilities for treatment in some of them, particularly since procedures are non-invasive, of low cost, and easily performed during initial heparin therapy.