RESUMO
We studied the sensitivity of H. pylori to clarithromycin and metronidazole, as well as the sensitivity and specificity of H. pylori culture, urease test and histology on a sample of 166 Portuguese patients. We observed a prevalence of 5.8% resistance to clarithromycin and 60% resistance to metronidazole. The sensitivity and specificity for the diagnostic tests were: culture 98% and 100%, urease test 98% and 91%, histology 50% and 95%, respectively.
Assuntos
Antibacterianos/antagonistas & inibidores , Claritromicina/antagonistas & inibidores , Helicobacter pylori/efeitos dos fármacos , Metronidazol/antagonistas & inibidores , Biópsia , Resistência Microbiana a Medicamentos , Gastroscopia , Infecções por Helicobacter/microbiologia , Infecções por Helicobacter/patologia , Helicobacter pylori/isolamento & purificação , Humanos , Testes de Sensibilidade Microbiana , Sensibilidade e Especificidade , Estômago/microbiologia , Estômago/patologiaAssuntos
Rejeição de Enxerto/imunologia , Sobrevivência de Enxerto/imunologia , Antígeno HLA-DR6/imunologia , Teste de Histocompatibilidade , Transplante de Rim/imunologia , Complicações Pós-Operatórias/imunologia , Ciclosporina/administração & dosagem , Quimioterapia Combinada , Rejeição de Enxerto/mortalidade , Rejeição de Enxerto/prevenção & controle , Sobrevivência de Enxerto/efeitos dos fármacos , Humanos , Tábuas de Vida , Metilprednisolona/administração & dosagem , Complicações Pós-Operatórias/mortalidade , Complicações Pós-Operatórias/prevenção & controle , Prednisolona/administração & dosagem , Estudos RetrospectivosRESUMO
OBJECTIVE: To clarify the influence of the HLA-DRB1 locus on the susceptibility to rheumatoid arthritis and the production of anti-cyclic citrullinated peptide antibodies (anti-CCP) in a Portuguese population. METHODS: 141 patients with rheumatoid arthritis fulfilling the American College of Rheumatology 1987 revised criteria for rheumatoid arthritis were compared with 150 healthy controls. Human leucocyte antigen (HLA)-DRB1 locus genotyping was assessed by polymerase chain reaction reverse probing assays and sequence-specific primers. Anti-CCP antibodies were quantified by ELISA in patients with rheumatoid arthritis. Frequencies between groups were compared by the two-sided Fisher's exact test and considered significant if p<0.05. RESULTS: The HLA-DRB1*04 and HLA-DRB1*10 groups were highly associated with rheumatoid arthritis (p<0.001 and p = 0.031, respectively). High titres of anti-CCP antibodies were largely associated with the presence of HLA-DRB1*04/10. CONCLUSION: The well-recognised susceptibility alleles to rheumatoid arthritis, HLA-DRB1*04, were associated with rheumatoid arthritis in Portuguese patients. The relatively rare DRB1*10 was also associated with rheumatoid arthritis, as was described previously in other southern European countries. Both groups were associated with high anti-CCP titres, reinforcing its relevance to disease onset.
Assuntos
Artrite Reumatoide/imunologia , Autoanticorpos/imunologia , Epitopos/imunologia , Antígenos HLA-DR/imunologia , Peptídeos Cíclicos/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Alelos , Artrite Reumatoide/genética , Estudos de Casos e Controles , Suscetibilidade a Doenças , Feminino , Genótipo , Cadeias HLA-DRB1 , Humanos , Imunofenotipagem , Masculino , Pessoa de Meia-Idade , Razão de Chances , Portugal , RiscoRESUMO
PIP: Patterns in labor migration from the Mediterranean region to the European Community are described.^ieng
Assuntos
Emigração e Imigração , Migrantes , Demografia , Países Desenvolvidos , Europa (Continente) , População , Dinâmica PopulacionalRESUMO
To investigate the possible relation between the DR4 antigen and IgM rheumatoid factors (RF). 80 patients with rheumatoid arthritis were tested for 7 HLA-DR antigens and 38 HLA-A, B, C antigens, and compared with 66 normal controls. The DR4 antigen prevalence was 48.7% in the patients and 12.1% in the controls (p less than 0.001). Studying the relationship between the HLA-DR4 antigen and IgM, the genetic marker was present in 89.7% of 51 seropositive patients and in 39% of 29 seronegatives (p less than 0.00001). On the other hand we discovered a positive association between HLA-DR3 and antinuclear antibodies (p less than 0.01). These results suggest the existence of immune response genes in the major histocompatibility complex of humans.